Michigan State University
My work is in the area of microbial pathogenicity, including host-microbe-microbiome interactions. We study transcription regulatory mechanisms, appling genetic, and biochemical approaches, and our work includes chemical biology and therapeutic discovery. We focus primarily on the pathogens Vibrio cholerae, Campylobacter jejuni, and antibiotic-resistant Enterobacter spp. We have also studied Group A streptococci in a mouse model of necrotizing fasciitis. Our interest is in biology and pathogenicity of microbes at different scales: from questions around single molecule biology and protein-protein interactions governing key processes, to genomic-level interrogation in animal models of infection, to the role of complex microbiota in pathogen-host biology. A major, and highly rewarding, interest has been training undergraduates, graduate students and postdoctoral fellows in the lab and towards developing their own path to the future.