Host-Microbe Biology Session Highlights from ASM Microbe 2019

Oct. 7, 2019

Purchase the ASM MICROBE 2019 - Host-Microbe Biology Package for $449 and get these 8 scientific sessions plus 10 more! 

Cancer Metagenomics: Microbes and Microbiomes

Since the discovery of cancer-initiating microbes, cancer biologists and microbiologist have been working together to understand how this relationship informs not only prevention and risk, but also prognosis and therapy. Critical findings have emerged that have been paradigm shifting and life-saving. Unlocking the potential of the microbiome and its individual members is an exciting endeavor but will require methodological diligence and collaboration between both fields. This symposium will allow the audience to understand the key relationships discovered between the microbiome and cancer, and to be able to identify the important factors necessary for cancer-microbiome studies.

This session features presentations from:
Cynthia (Cindy) Sears, Johns Hopkins University
Patrick Schloss, University of Michigan
Daniel Slade, Virginia Tech
Marina Walther-Antonio, Mayo Clinic

Watch: Cancer Metagenomics: Microbes and Microbiomes
(Note: video playback requires the purchase of either the HMB or ASM Microbe 2019 packages.)
 

Message in a Bubble: Extracelular Vesicles and Microbial Pathogenesis

Pathogens have a remarkable armamentarium of processes that effectively subvert, evade and combat host response. Extracellular vesicles have been associated with the pathogenesis of diverse microbes, including viruses, bacteria, fungi and parasites. This symposia will highlight the import of extracellular vesicles in a rich variety of pathogens, including how Dengue virus highjacks host cell exosomes, how vesicles produced by Staphylococcus aureus can be leveraged for vaccine development, how fungi deliver macromolecular pathogenic compounds to the extracellular space, and more. The talks will thus show how these structures can undermine host responses (function as “Trojan horses” or "virulence bags") or alternatively bolster immunity (function as a vaccine). The speakers will also underscore how processes linked to vesicle production can be targeted for drug development. The session will foster future investigations into this remarkable area of biology.

This session features presentations from:
Jared Silverman, Bill and Melinda Gate Medical Research Institute
Hameeda Sultana, Old Dominion University
Marcio Rodrigues, Fundação Oswaldo Cruz (Fiocruz)
Watch: Message in a Bubble: Extracelular Vesicles and Microbial Pathogenesis
(Note: video playback requires the purchase of either the HMB or ASM Microbe 2019 packages.)

ER Stressing Out: Microbial Manipulation of the Endoplasmic Reticulum Stress Response

In this session you will learn that a variety of microbes invoke the endoplasmic reticulum (ER) stress, which is intimately linked to activation and control of innate immunity responses. Many microbes also manipulate host ER stress responses to promote their growth. This symposium will highlight the latest research on the interface between innate immune signaling and ER stress, novel microbial mechanisms to modulate the ER stress response, and new concepts for the role of ER stress in microbial community development.

This session features presentations from:
Kimberly Klein, Nanyang Technological University
Mary O’Riordan, University of Michigan
Renee Rsolis, University of California, Davis
Watch: ER Stressing Out: Microbial Manipulation of the Endoplasmic Reticulum Stress Response
(Note: video playback requires the purchase of either the HMB or ASM Microbe 2019 packages.)
 

Host Modulation: Who's in Control?

The purpose of the session is to discuss research related to recent developments in our understanding of how diverse microbes, including bacteria, viruses and fungi, manipulate host behavior. Talks in this session will define coevolution and distinguish aspects of this process that are unique to bacteria and phage.

This session features presentations from:
Matthew Kasson, West Virginia University
Vera Ros, Wageningen University and Research
Teresa Pawlowska, Cornell University
Michael Shiloh, University of Texas, Southwestern
Watch: Host Modulation: Who's in Control?
(Note: video playback requires the purchase of either the HMB or ASM Microbe 2019 packages.)
 
 

Directing the Digester: How Pathogens Use Lysosomes to Build an Intracellular Niche

Lysosomes play a key role in immunity by their contributions to pathogen elimination and antigen presentation. Most intracellular pathogens have developed strategies to avoid these catabolic organelles. Some species have also developed sophisticated mechanisms to exploit lysosomes. This symposium will illustrate these interactions through examples found in bacteria (e.g. Coxiella, Listeria) that manipulate lysosomes of the host cell, and eukaryotic microbes that use their own lysosomes, to persist.

This session features presentations from:
Helene Bierne, French National Institute for Agricultural Research (INRA)
David Smith, University of Michigan
Craig Roy, Yale University
Watch: Directing the Digester: How Pathogens Use Lysosomes to Build an Intracellular Niche
(Note: video playback requires the purchase of either the HMB or ASM Microbe 2019 packages.)
 

Stuck on You: Mucin-Microbe Interplay in Health and Disease

Mucin glycoproteins play a critical role in governing the structure and function of our microbiota. Mucins are critical components of host defense that protect epithelia from pathogens, yet they also harbor commensal microbiota and represent an abundant bacterial nutrient source in the gut, airways, reproductive tract and oral cavity. This symposium highlights recent advances in mucin-microbe dynamics, and how we can exploit these interactions to promote healthy microbiota and prevent disease.

This session features presentations from:
Katharina Ribbeck, Massachussetts Institute of Technology
Melinda Engevik, Baylor College of Medicine
Jeremy Barr, Monash University
Watch: Stuck on You: Mucin-Microbe Interplay in Health and Disease
(Note: video playback requires the purchase of either the HMB or ASM Microbe 2019 packages.)
 

Not Food for Thought: Microbial and Host Metabolism in Infectious Diseases

It is generally accepted that metabolic pathways are essential in all forms of life for the obvious reasons of growth and reproduction. More recently we have started to appreciate that microbes and their hosts can subvert or weaponize metabolism for their respective survival. This session will examine new concepts using traditional to state-of-the-art techniques to determine how metabolic products contribute to microbial pathogenesis and host defense.

This session features presentations from:
Anthony Richardson, University of Pittsburgh
Joseph Zackular, University of Pennsylvania
Sarah Stanley, University of California, Berkeley
Watch: Not Food for Thought: Microbial and Host Metabolism in Infectious Diseases
(Note: video playback requires the purchase of either the HMB or ASM Microbe 2019 packages.)
 

Infection Pathophysiology and Immune Responses

Pathogenic microbes typically interact with numerous host processes, including but not limited to cell signaling, cell death, metabolism, and healing. The pathophysiology of infection can impact disease symptoms, disease progression, and the pharmacology and pharmacokinetics of therapeutics like antibiotics. This session explores the relationship between the microbe and the infected body site, and how this impacts the contribution of a microbe’s virulence factors and the coordination of an effective immune response.

This session features presentations from:
Carlos Orihuela, University of Alabama, Birmingham
Suzanne Fleiszig, University of California, Berkeley
Elizabeth Grice, University of Pennsylvania
Watch: Infection Pathophysiology and Immune Responses
(Note: video playback requires the purchase of either the HMB or ASM Microbe 2019 packages.)
Purchase ASM Microbe 2019 Recordings

Author: ASM Communications

ASM Communications
ASM Communications staff.