Basic Virology
Find the latest information on the basic research on SARS-CoV-2 and other coronaviruses. Information is organized intosubcategories:RNA Replication
Proteins & Translation
January 2021
- *NEW *Research Tool SARS-CoV-2 protein ORF3a is pathogenic in Drosophila and causes phenotypes associated with COVID-19 post-viral syndrome.
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Virus Assembly, Protein Processing and Structure
January 2021
- Articles to be updated shortly.
December 2020
- Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.
- The SARS-CoV-2 Envelope and Membrane proteins modulate maturation and retention of the Spike protein, allowing assembly of virus-like particles.
- Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein.
- Architecture of a SARS-CoV-2 mini replication and transcription complex.
- Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.
- SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography.
- *Research Tool SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles.
November 2020
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Evolution & Phylogenetics
January 2021
- *NEW Recombination events are concentrated in the spike protein region of Betacoronaviruses.
- Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Evolutionary and structural analysis of SARS-CoV-2 specific evasion of host immunity.
December 2020
- No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2.
- Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan.
November 2020
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Host Immune Response
January 2021
- *NEW Kinetics of antibody responses dictate COVID-19 outcome.
- *NEW The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates.
- *NEW Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid.
- *NEW Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.
- *NEW Impact of B.1.1.7 variant mutations on antibody recognition of linear SARS-CoV-2 epitopes.
- Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison.
December 2020
- *Research Tool Global analysis of protein-RNA interactions in SARS-CoV-2 infected cells reveals key regulators of infection.
- Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection.
- Dynamic changes in anti-SARS-CoV-2 antibodies during SARS-CoV-2 infection and recovery from COVID-19.
- Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.
- *Research Tool Genetic mechanisms of critical illness in Covid-19.
- Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
- Opposing activities of IFITM proteins in SARS-CoV-2 infection.
- Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients.
- *Research Tool Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.
- Proinflammatory IgG Fc structures in patients with severe COVID-19.
November 2020
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Animal Models & Epizootic Infections
January 2021
- *NEW Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets.
December 2020
- STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
- SARS-CoV-2 Transmission between Mink (Neovison vison) and Humans, Denmark.
- Correlates of protection against SARS-CoV-2 in rhesus macaques.
- A zebrafish model for COVID-19 recapitulates olfactory and cardiovascular pathophysiologies caused by SARS-CoV-2.
- Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans.
- Establishment of an African green monkey model for COVID-19 and protection against re-infection.
- Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection.
- Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
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Viral Entry & Receptors
January 2021
- *NEW The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins.
- *NEW Cross-species recognition of SARS-CoV-2 to bat ACE2.
- *NEW *Research Tool Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses.
- *NEW SARS-CoV-2 spike downregulates tetherin to enhance viral spread.
- *NEW SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor.
- *NEW The SARS-CoV-2 spike protein disrupts the cooperative function of human cardiac pericytes - endothelial cells through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease.
- Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects.
- *Research Tool SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia Formation.
- Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses.
- D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.
December 2020
- *Research Tool Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.
- SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity.
- Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
- CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells.
- COVID-19-associated olfactory dysfunction reveals SARS-CoV-2 neuroinvasion and persistence in the olfactory system.
- Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles.
- HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry.
November 2020
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Viral Replication/Non-Structural Proteins/Enzymes
January 2021
- Articles to be updated shortly.
December 2020
- *Research Tool Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies.
- The global and local distribution of RNA structure throughout the SARS-CoV-2 genome.
October 2020
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