Basic Virology
Find the latest information on the basic research on SARS-CoV-2 and other coronaviruses. Information is organized into subcategories:
RNA Replication
Proteins & Translation
April 2021
January 2021
- *Research Tool In vivo structure and dynamics of the RNA genome of SARS-Cov-2.
- *Research Tool SARS-CoV-2 protein ORF3a is pathogenic in Drosophila and causes phenotypes associated with COVID-19 post-viral syndrome.
2020
Back to TopVirus Assembly, Protein Processing and Structure
April 2021
- *NEW Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN.
- *NEW Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.
March 2021
- Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity.
- A metal ion orients mRNA to ensure accurate 2'-O ribosyl methylation of the first nucleotide of the SARS-CoV-2 genome.
- Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication.
- *Research Tool In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.
- The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion Release.
- Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP.
- Insights into the secondary structural ensembles of the full SARS-CoV-2 RNA genome in infected cells.
- The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2.
- Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids.
- Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14+ monocytes.
- Structural Basis for Accommodation of Emerging B.1.351 and B.1.1.7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies.
January 2021
2020
Back to TopEvolution & Phylogenetics
April 2021
- *NEW Preliminary report on SARS-CoV-2 Spike mutation T478K.
- *NEW Genomic surveillance of SARS-CoV-2 tracks early interstate transmission of P.1 lineage and diversification within P.2 clade in Brazil.
March 2021
- The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the Spike protein.
- Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation.
- SARS-CoV-2 within-host diversity and transmission.
- The emergence and ongoing convergent evolution of the N501Y lineages coincides with a major global shift in the SARS-CoV-2 selective landscape.
- Emergence of a SARS-CoV-2 variant of concern with mutations in spike glycoprotein.
- Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil.
- Acquisition of the L452R mutation in the ACE2-binding interface of Spike protein triggers recent massive expansion of SARS-Cov-2 variants.
- A SARS-CoV-2 lineage A variant (A.23.1) with altered spike has emerged and is dominating the current Uganda epidemic.
- Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hot Spots, Functional Cross Talk, and Regulatory Interactions in SARS-CoV-2.
- A Novel SARS-CoV-2 Variant of Concern, B.1.526, Identified in New York.
- Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses.
- Genomic epidemiology identifies emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States.
- Sixteen novel lineages of SARS-CoV-2 in South Africa.
- Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia.
- Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677.
- Molecular Evolution of Human Coronavirus 229E in Hong Kong and a Fatal COVID-19 Case Involving Coinfection with a Novel Human Coronavirus 229E Genogroup.
- SARS-CoV-2 lineage B.1.526 emerging in the New York region detected by software utility created to query the spike mutational landscape.
February 2021
January 2021
2020
Back to TopHost Immune Response
April 2021
- Articles to be updated shortly.
March 2021
- *Research Tool COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.
- *Research Tool Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions.
- Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells.
- *Research Tool Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses.
- Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19.
- The spatial landscape of lung pathology during COVID-19 progression.
- COVID-19-neutralizing antibodies predict disease severity and survival.
- Diverse Functional Autoantibodies in Patients with COVID-19.
February 2021
January 2021
2020
Back to TopAnimal Models & Epizootic Infections
April 2021
- Articles to be updated shortly.
March 2021
- Contribution of SARS-CoV-2 accessory proteins to viral pathogenicity in K18 hACE2 transgenic mice.
- Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2.
- SARS-CoV-2 Exposure in Escaped Mink, Utah, USA.
February 2021
January 2021
2020
Back to TopViral Entry & Receptors
April 2021
- *NEW Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry.
- *NEW Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2.
March 2021
- Identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species.
- Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2.
- Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2.
- The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization.
- Differential gene expression by RNA-Seq in Sigma-2 Receptor/TMEM97 knockout cells reveals its role in complement activation and SARS-CoV-2 viral uptake.
- Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication.
- Research Tool The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice.
- Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell.
- Research Tool SARS-CoV-2 comprehensive receptor profiling: mechanistic insight to drive new therapeutic strategies.
- Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.
- SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction.
- Research Tool Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
- Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2.
- A common TMPRSS2 variant protects against severe COVID-19.
- Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.
- The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types.
- SARS-CoV-2 spike D614G change enhances replication and transmission.
- SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas.
- The basis of a more contagious 501Y.V1 variant of SARS-COV-2.
- SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation.
- Biomechanical Characterization of SARS-CoV-2 Spike RBD and Human ACE2 Protein-Protein Interaction.