Clinical Diagnostics
Find the latest research on a wide range of molecular and serological assays currently available or under development:
Detection of Virus and Its Components (including Molecular Diagnostics)
April 2020
- Development and potential usefulness of the COVID-19 Ag Respi-Strip diagnostic assay in a pandemic context.
- Evaluation of the QIAstat-Dx Respiratory SARS-CoV-2 Panel, the first rapid multiplex PCR commercial assay for SARS-CoV-2 detection.
- Evaluation of Transport Media and Specimen Transport Conditions for the Detection of SARS-CoV-2 Using Real Time Reverse Transcription PCR.
- Evaluation of WHO listed COVID-19 qPCR primers and probe in silico with 375 SERS-CoV-2 full genome sequences.
- A rapid, low cost, and highly sensitive SARS-CoV-2 diagnostic based on whole genome sequencing.
- Clinical Evaluation of Three Sample-To-Answer Platforms for the Detection of SARS-CoV-2.
- Comparison of Abbott ID Now and Abbott m2000 methods for the detection of SARS-CoV-2 from nasopharyngeal and nasal swabs from symptomatic patients.
- Comparison of Commercially Available and Laboratory Developed Assays for in vitro Detection of SARS-CoV-2 in Clinical Laboratories.
- The Detection of SARS-CoV-2 using the Cepheid Xpert Xpress SARS-CoV-2 and Roche cobas SARS-CoV-2 Assays.
- Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study.
- Laboratory diagnosis of emerging human coronavirus infections - the state of the art.
- Report from the American Society for Microbiology COVID-19 International Summit, 23 March 2020: Value of Diagnostic Testing for SARS–CoV-2/COVID-19.
- The Laboratory Diagnosis of COVID-19 Infection: Current Issues and Challenges.
- Emergence of a Novel Coronavirus (COVID-19): Protocol for Extending Surveillance Used by the Royal College of General Practitioners Research and Surveillance Centre and Public Health England.
- Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.
May 2020
- Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets.
- Validation of SARS-CoV-2 detection across multiple specimen types.
- Phenol-chloroform-based RNA purification for detection of SARS-CoV-2 by RT-qPCR: comparison with automated systems.
- Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-1 SARS-CoV-2 and a clinical isolate of SARS-CoV-2.
- Viral loads in throat and anal swabs in children infected with SARS-CoV-2.
- Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure.
- A multiple center clinical evaluation of an ultra-fast single-tube assay for SARS-CoV-2 RNA.
- Testing Dilemmas: Post negative, positive SARS-CoV-2 RT-PCR – is it a reinfection?
- US CDC Real-Time Reverse Transcription PCR Panel for Detection of Severe Acute Respiratory Syndrome Coronavirus 2.
- Performance of the rapid Nucleic Acid Amplification by Abbott ID NOW COVID-19 in nasopharyngeal swabs transported in viral media and dry nasal swabs, in a New York City academic institution.
- Multicenter Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 Test.
- Comparing the analytical performance of three SARS-CoV-2 molecular diagnostic assays.
- Sensitivity assessment of SARS-CoV-2 PCR assays developed by WHO referral laboratories.
- Diagnostic performance between CT and initial real-time RT-PCR for clinically suspected 2019 coronavirus disease (COVID-19) patients outside Wuhan, China.
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Serology (including Neutralization)
April 2020
- Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020.
- SARS-CoV-2 serological analysis of COVID-19 hospitalized patients, pauci-symptomatic individuals and blood donors.
- Test performance evaluation of SARS-CoV-2 serological assays.
- Detection of Nucleocapsid Antibody to SARS-CoV-2 is More Sensitive than Antibody to Spike Protein in COVID-19 Patients.
- Diagnostic accuracy of an automated chemiluminescent immunoassay for anti-SARS-CoV-2 IgM and IgG antibodies: an Italian experience.
- Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor.
- Antibody Detection and Dynamic Characteristics in Patients with COVID-19.
- Evaluation of antibody testing for SARS-Cov-2 using ELISA and lateral flow immunoassays.
- The convalescent sera option for containing COVID-19.
- Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease 2019 Patients.
- Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019.
- Evaluation of Nucleocapsid and Spike Protein-based ELISAs for detecting antibodies against SARS-CoV-2.
- Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2.
May 2020
- Serology characteristics of SARS-CoV-2 infection since exposure and post symptom onset.
- SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area.
- Standardization of enzyme-linked immunosorbent assays for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling.
- Detection of Nucleocapsid Antibody to SARS-CoV-2 is More Sensitive than Antibody to Spike Protein in COVID-19 Patients.
- Longitudinal Monitoring of SARS-CoV-2 IgM and IgG Seropositivity to Detect COVID-19.
- A serological assay to detect SARS-CoV-2 seroconversion in humans.
- Evaluation of two automated and three rapid lateral flow immunoassays for the detection of anti-SARS-CoV-2 antibodies.
- Clinical Performance of Two SARS-CoV-2 Serologic Assays.
- Evaluation of commercial and automated SARS-CoV-2 IgG and IgA ELISAs using coronavirus disease (COVID-19) patient samples.
- Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.
- Serology assays to manage COVID-19.
- ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens.
- Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model.
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