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Clinical Diagnostics
Find the latest research on a wide range of molecular and serological assays currently available or under development:
Detection of Virus and Its Components (including Molecular Diagnostics)
April 2021
March 2021
- Droplet Digital RT-PCR to detect SARS-CoV-2 variants of concern in wastewater.
- Performance and operational feasibility of antigen and antibody rapid diagnostic tests for COVID-19 in symptomatic and asymptomatic patients in Cameroon: a clinical, prospective, diagnostic accuracy study.
- Prolonged Unfrozen Storage and Repeated Freeze-Thawing of SARS-CoV-2 Patient Samples Have Minor Effects on SARS-CoV-2 Detectability by RT-PCR.
- Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data.
- Specificity of SARS-CoV-2 Real-Time PCR Improved by Deep Learning Analysis.
- Detection of Mutations Associated with Variants of Concern Via High Throughput Sequencing of SARS-CoV-2 Isolated from NYC Wastewater.
- High-Throughput Wastewater SARS-CoV-2 Detection Enables Forecasting of Community Infection Dynamics in San Diego County.
- Saliva as a testing specimen with or without pooling for SARS-CoV-2 detection by multiplex RT-PCR test.
- Performance and Implementation Evaluation of the Abbott BinaxNOW Rapid Antigen Test in a High-throughput Drive-through Community Testing Site in Massachusetts.
- Detecting SARS-CoV-2 variants with SNP genotyping.
- S-variant SARS-CoV-2 lineage B1.1.7 is associated with significantly higher viral loads in samples tested by ThermoFisher TaqPath RT-qPCR.
February 2021
- Performance Characteristics of BinaxNOW COVID-19 Antigen Card for Screening Asymptomatic Individuals in a University Setting.
- Real-life validation of the Panbio™ COVID-19 antigen rapid test (Abbott) in community-dwelling subjects with symptoms of potential SARS-CoV-2 infection.
- Performance of Oropharyngeal Swab Testing Compared With Nasopharyngeal Swab Testing for Diagnosis of Coronavirus Disease 2019-United States, January 2020-February 2020.
- Insight into the practical performance of RT-PCR testing for SARS-CoV-2 using serological data: a cohort study.
- Diagnostic Accuracy of the Panbio SARS-CoV-2 Antigen Rapid Test Compared with Rt-Pcr Testing of Nasopharyngeal Samples in the Pediatric Population.
January 2021
- Evaluation of Abbott BinaxNOW Rapid Antigen Test for SARS-CoV-2 Infection at Two Community-Based Testing Sites - Pima County, Arizona, November 3-17, 2020.
- Strand-Specific Reverse Transcription PCR for Detection of Replicating SARS-CoV-2.
- Development of a quantitative one-step multiplex RT-qPCR assay for the detection of SARS-CoV-2 in a biological matrix.
- Digital droplet PCR accurately quantifies SARS-CoV-2 viral load from crude lysate without nucleic acid purification.
- Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2: A Systematic Review and Meta-analysis.
- Development of a saliva-optimized RT-LAMP assay for SARS-CoV-2.
- Diagnostic performance and clinical implications of rapid SARS-CoV-2 antigen testing in Mexico using real-world nationwide COVID-19 registry data.
- Direct detection of SARS-CoV-2 RNA using high-contrast pH-sensitive dyes.
- IGI-LuNER: single-well multiplexed RT-qPCR test for SARS-CoV-2.
- Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy.
- A smartphone-read ultrasensitive and quantitative saliva test for COVID-19.
- *Research Tool Rapid detection of SARS-CoV-2 with Cas13.
- Reliable and accurate diagnostics from highly multiplexed sequencing assays.
- Rapid and sensitive detection of SARS-CoV-2 antibodies by biolayer interferometry.
- Rapid detection of SARS-CoV-2 with CRISPR-Cas12a.
- Variable sensitivity in molecular detection of SARS-CoV-2 in European Expert Laboratories: External Quality Assessment, June – July 2020.
2020
December 2020
- Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA.
- *Research Tool A Fast and Accessible Method for the Isolation of RNA, DNA, and Protein to Facilitate the Detection of SARS-CoV-2.
- Comparison of 12 Molecular Detection Assays for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
- Evaluation of the Panbio rapid antigen test for SARS-CoV-2 in primary health care centers and test sites.
- Inference of Active Viral Replication in Cases with Sustained Positive RT-PCRs for SARS-CoV-2.
- Clinical performance of the point-of-care cobas Liat for detection of SARS-CoV-2 in 20 minutes: A multicenter study.
- Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2.
- An enhanced isothermal amplification assay for viral detection.
November 2020
- Point-of-care detection of SARS-CoV-2 in nasopharyngeal swab samples using an integrated smartphone-based centrifugal microfluidic platform.
- Electric field-driven microfluidics for rapid CRISPR-based diagnostics and its application to detection of SARS-CoV-2.
- SARSeq, a robust and highly multiplexed NGS assay for parallel detection of SARS-CoV2 and other respiratory infections.
- SARS-CoV-2 detection by nasal strips: a superior tool for surveillance of pediatric populations.
- Diagnosis of COVID-19 by analysis of breath with gas chromatography-ion mobility spectrometry - a feasibility study.
October 2020
- A Sensitive, Rapid, and Portable CasRx-based Diagnostic Assay for SARS-CoV2.
- Saliva as testing sample for SARS-CoV-2 detection by RT-PCR in low prevalence community setting.
- Performance of a multiplex polymerase chain reaction panel for identifying bacterial pathogens causing pneumonia in critically ill patients with COVID-19.
- A pooled testing strategy for identifying SARS-CoV-2 at low prevalence.
- The Effect of Sample Site, Illness Duration, and the Presence of Pneumonia on the Detection of SARS-CoV-2 by Real-time Reverse Transcription PCR.
- Assessing a novel, lab-free, point-of-care test for SARS-CoV-2 (CovidNudge): a diagnostic accuracy study.
- Hitting the diagnostic sweet spot: Point-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf glucometer.
- *Research Tool Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR.
September 2020
- Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing.
- Digital droplet PCR accurately quantifies SARS-CoV-2 viral load from crude lysate without nucleic acid purification.
- SARS-CoV-2 identification and IgA antibodies in saliva: one sample two tests approach for diagnosis.
- Sensitive fluorescence detection of SARS-CoV-2 RNA in clinical samples via one-pot isothermal ligation and transcription.
- Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay.
- Saliva as a Candidate for COVID-19 Diagnostic Testing: A Meta-Analysis.
- A role for Biofoundries in rapid development and validation of automated SARS-CoV-2 clinical diagnostics.
- Efficient high-throughput SARS-CoV-2 testing to detect asymptomatic carriers.
- Self-collected Saline Gargle Samples as an Alternative to Healthcare Worker Collected Nasopharyngeal Swabs for COVID-19 Diagnosis in Outpatients.
- Detection of SARS-CoV-2 with SHERLOCK One-Pot Testing.
- Pooling saliva to increase SARS-CoV-2 testing capacity.
- Detection and quantification of SARS-CoV-2 by droplet digital PCR in real-time PCR negative nasopharyngeal swabs from suspected COVID-19 patients.
- Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA.
- The Interpretation of SARS-CoV-2 Diagnostic Tests.
- SalivaDirect: Simple and sensitive molecular diagnostic test for SARS-CoV-2 surveillance.
August 2020
- Saliva sample pooling for the detection of SARS-CoV-2.
- Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath.
- CT Vascular Tree-in-bud: A Novel Prognostic Imaging Biomarker in COVID-19?
- Non-invasive saliva specimens for the diagnosis of COVID-19: caution in mild outpatient cohorts with low prevalence.
- Performance Characteristics of a High-Throughput Automated Transcription-Mediated Amplification Test for SARS-CoV-2 Detection.
- Prospective study comparing deep-throat saliva with other respiratory tract specimens in the diagnosis of novel coronavirus disease (COVID-19).
- Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics.
- A Novel Multiplex qRT-PCR Assay to Detect SARS-CoV-2 Infection: High Sensitivity and Increased Testing Capacity.
- A colorimetric RT-LAMP assay and LAMP-sequencing for detecting SARS-CoV-2 RNA in clinical samples.
- Comparison of Unsupervised Home Self-collected Midnasal Swabs With Clinician-Collected Nasopharyngeal Swabs for Detection of SARS-CoV-2 Infection.
- Proteotyping SARS-CoV-2 virus from nasopharyngeal swabs: a proof-of-concept focused on a 3 min mass spectrometry window.
- Saliva Sampling and Its Direct Lysis, an Excellent Option To Increase the Number of SARS-CoV-2 Diagnostic Tests in Settings with Supply Shortages.
- A Recurrent Mutation at Position 26340 of SARS-CoV-2 Is Associated with Failure of the E Gene Quantitative Reverse Transcription-PCR Utilized in a Commercial Dual-Target Diagnostic Assay.
July 2020
- A recurrent mutation at position 26,340 of SARS-CoV-2 is associated with failure of the E-gene qRT-PCR utilized in a commercial dual-target diagnostic assay.
- Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT-qPCR primer-probe sets.
- Use of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in COVID-19.
- Comparison of two commercial platforms and a laboratory developed test for detection of SARS-CoV-2 RNA.
- Novel multiple swab method enables high efficiency in SARS-CoV-2 screenings without loss of sensitivity for screening of a complete population.
- Advances in Detection of Infectious Agents by Aptamer-based Technologies.
- Deep throat saliva as an alternative diagnostic specimen type for the detection of SARS-CoV-2.
- Utility of Stool PCR for the Diagnosis of COVID-19: Comparison of Two Commercial Platforms.
- Assessment of sample pooling for clinical SARS-CoV-2 testing.
- Simulation of Pool Testing to Identify Patients With Coronavirus Disease 2019 Under Conditions of Limited Test Availability.
- Culture-based virus isolation to evaluate potential infectivity 1 of clinical specimens tested for COVID-19.
- Mass Spectrometric Identification of SARS-CoV-2 Proteins from Gargle Solution Samples of COVID-19 Patients.
- Nanotrap(R) particles improve detection of SARS-CoV-2 for pooled sample methods, extraction-free saliva methods, and extraction-free medium methods.
June 2020
- Evaluation of specimen types and saliva stabilization solutions for SARS-CoV-2 testing.
- Culture-based virus isolation to evaluate potential infectivity of clinical specimens tested for COVID-19.
- Propagation, Inactivation, and Safety Testing of SARS-CoV-2.
- First detection of SARS-CoV-2 by real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay in pleural fluid.
- Clinical Performance of SARS-CoV-2 Molecular Tests.
- Pitfalls in SARS-CoV-2 PCR Diagnostics.
- Field-deployable, rapid diagnostic testing of saliva samples for SARS-CoV-2.
- Clinical evaluation of self-collected saliva by RT-qPCR, direct RT-qPCR, RT-LAMP, and a rapid antigen test to diagnose COVID-19.
- Comparative Performance of SARS-CoV-2 Detection Assays using Seven Different Primer/Probe Sets and One Assay Kit.
- Direct RT-qPCR Detection Of SARS-CoV-2 RNA From Patient Nasopharyngeal Swabs Without An RNA Extraction Step.
- Clinical Performance of the Luminex NxTAG CoV Extended Panel for SARS-CoV-2 Detection in Nasopharyngeal Specimens from COVID-19 Patients in Hong Kong.
- Clinical performance of different SARS-CoV-2 IgG antibody tests.
- Brief clinical evaluation of six high-throughput SARS-CoV-2 IgG antibody assays.
- Evaluation of rapid diagnosis of novel coronavirus disease (COVID-19) using loop-mediated isothermal amplification.
- Occurrence and Timing of Subsequent SARS-CoV-2 RT-PCR Positivity Among Initially Negative Patients.
- Homogeneous circle-to-circle amplification for real-time optomagnetic detection of SARS-CoV-2 RdRp coding sequence.
- SARS-CoV-2 antibody characterization in emergency department, hospitalized and convalescent patients by two semi-quantitative immunoassays.
- Clinical Performance of SARS-CoV-2 Molecular Testing.
- Performance Characteristics of Four High-Throughput Immunoassays for Detection of IgG Antibodies against SARS-CoV-2.
- An Inexpensive RT-PCR Endpoint Diagnostic Assay for SARS-CoV-2 Using Nested PCR: Direct Assessment of Detection Efficiency of RT-qPCR Tests and Suitability for Surveillance.
- Shortlisting SARS-CoV-2 Peptides for Targeted Studies from Experimental Data-Dependent Acquisition Tandem Mass Spectrometry Data.
- Comparison of the Accula SARS-CoV-2 Test with a Laboratory-Developed Assay for Detection of SARS-CoV-2 RNA in Clinical Nasopharyngeal Specimens.
- Comparison of two commercial molecular tests and a laboratory-developed modification of the CDC 2019-nCoV RT-PCR assay for the detection of SARS-CoV-2.
- SYBR Green-based one-step qRT-PCR for the detection of SARS-CoV-2 RNA in saliva.
- Test Agreement between Roche Cobas 6800 and Cepheid GeneXpert Xpress SARS-CoV-2 Assays at High Cycle Threshold Ranges.
- Implication of SARS-CoV-2 evolution in the sensitivity of RT-qPCR diagnostic assays.
- Improved sensitivity using a dual target, E and RdRp assay for the diagnosis of SARS-CoV-2 infection: Experience at a large NHS Foundation Trust in the UK.
- Two Detailed Plaque Assay Protocols for the Quantification of Infectious SARS-CoV-2.
- Performance of Abbott ID Now COVID-19 Rapid Nucleic Acid Amplification Test Using Nasopharyngeal Swabs Transported in Viral Media and Dry Nasal Swabs in a New York City Academic Institution.
- Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients.
- Rapid and accurate detection of novel coronavirus SARS-CoV-2 using CRISPR-Cas3.
- Detection of SARS-CoV-2 neutralizing antibodies with a cell-free PCR assay.
May 2020
- Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets.
- Validation of SARS-CoV-2 detection across multiple specimen types.
- Phenol-chloroform-based RNA purification for detection of SARS-CoV-2 by RT-qPCR: comparison with automated systems.
- Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-1 SARS-CoV-2 and a clinical isolate of SARS-CoV-2.
- Viral loads in throat and anal swabs in children infected with SARS-CoV-2.
- Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure.
- A multiple center clinical evaluation of an ultra-fast single-tube assay for SARS-CoV-2 RNA.
- Testing Dilemmas: Post negative, positive SARS-CoV-2 RT-PCR – is it a reinfection?
- US CDC Real-Time Reverse Transcription PCR Panel for Detection of Severe Acute Respiratory Syndrome Coronavirus 2.
- Performance of the rapid Nucleic Acid Amplification by Abbott ID NOW COVID-19 in nasopharyngeal swabs transported in viral media and dry nasal swabs, in a New York City academic institution.
- Multicenter Evaluation of the Cepheid Xpert Xpress SARS-CoV-2 Test.
- Comparing the analytical performance of three SARS-CoV-2 molecular diagnostic assays.
- Sensitivity assessment of SARS-CoV-2 PCR assays developed by WHO referral laboratories.
- Diagnostic performance between CT and initial real-time RT-PCR for clinically suspected 2019 coronavirus disease (COVID-19) patients outside Wuhan, China.
April 2020
- Development and potential usefulness of the COVID-19 Ag Respi-Strip diagnostic assay in a pandemic context.
- Evaluation of the QIAstat-Dx Respiratory SARS-CoV-2 Panel, the first rapid multiplex PCR commercial assay for SARS-CoV-2 detection.
- Evaluation of Transport Media and Specimen Transport Conditions for the Detection of SARS-CoV-2 Using Real Time Reverse Transcription PCR.
- Evaluation of WHO listed COVID-19 qPCR primers and probe in silico with 375 SERS-CoV-2 full genome sequences.
- A rapid, low cost, and highly sensitive SARS-CoV-2 diagnostic based on whole genome sequencing.
- Clinical Evaluation of Three Sample-To-Answer Platforms for the Detection of SARS-CoV-2.
- Comparison of Abbott ID Now and Abbott m2000 methods for the detection of SARS-CoV-2 from nasopharyngeal and nasal swabs from symptomatic patients.
- Comparison of Commercially Available and Laboratory Developed Assays for in vitro Detection of SARS-CoV-2 in Clinical Laboratories.
- The Detection of SARS-CoV-2 using the Cepheid Xpert Xpress SARS-CoV-2 and Roche cobas SARS-CoV-2 Assays.
- Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study.
- Laboratory diagnosis of emerging human coronavirus infections - the state of the art.
- Report from the American Society for Microbiology COVID-19 International Summit, 23 March 2020: Value of Diagnostic Testing for SARS–CoV-2/COVID-19.
- The Laboratory Diagnosis of COVID-19 Infection: Current Issues and Challenges.
- Emergence of a Novel Coronavirus (COVID-19): Protocol for Extending Surveillance Used by the Royal College of General Practitioners Research and Surveillance Centre and Public Health England.
- Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.
Serology (including Neutralization)
April 2021
- Articles to be updated shortly.
March 2021
- AACC Practical Recommendations for Implementing and Interpreting SARS-CoV-2 EUA and LDT Serologic Testing in Clinical Laboratories.
- Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity.
- Panbio™ rapid antigen test for SARS-CoV-2 has acceptable accuracy in symptomatic patients in primary health care.
- Comparison of sixteen serological SARS-CoV-2 immunoassays in sixteen clinical laboratories.
- *Research Tool Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera.
February 2021
- A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patients.
- Comparative performance of multiplex salivary and commercially available serologic assays to detect SARS-CoV-2 IgG and neutralization titers.
- A New SARS CoV-2 Dual Purpose Serology Test: Highly Accurate Infection Tracing and Neutralizing Antibody Response Detection.
- Evaluation of spike protein antigens for SARS-CoV-2 serology.
- Limited specificity of SARS-CoV-2 antigen-detecting rapid diagnostic tests at low temperatures.
- A flexible, pan-species, multi-antigen platform for the detection and monitoring of SARS-CoV-2-specific antibody responses.
January 2021
- *Research Tool Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS-CoV-2 spike protein.
- Comparison of Antibody Class Specific SARS-CoV-2 Serology for the Diagnosis of Acute COVID-19.
- *Research Tool Analysis of SARS-CoV-2 antibodies in COVID-19 convalescent blood using a coronavirus antigen microarray.
- Standardization of ELISA protocols for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling.
- Immunologic testing for SARS-CoV-2 infection from the antigen perspective.
- Development of a Rapid Point-Of-Care Test that Measures Neutralizing Antibodies to SARS-CoV-2.
- Characterization of a Pan-Immunoglobulin Assay Quantifying Antibodies Directed against the Receptor Binding Domain of the SARS-CoV-2 S1-Subunit of the Spike Protein: A Population-Based Study.
2020
December 2020
- Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS-CoV-2 Neutralizing Antibodies.
- A betacoronavirus multiplex microsphere immunoassay detects early SARS-CoV-2 seroconversion and antibody cross reactions.
- Development of a SERS-based lateral flow immunoassay for rapid and ultra-sensitive detection of anti-SARS-CoV-2 IgM/IgG in clinical samples.
- Antibody tests have higher sensitivity at ≥15 days after symptom onset and 99% specificity for detecting SARS-CoV-2.
- Evaluation of Serological SARS-CoV-2 Lateral Flow Assays for Rapid Point of Care Testing.
- Performance of the COVID-19 SEROSpeed IgM/IgG Rapid Test, an immunochromatographic assay for the diagnosis of SARS-CoV-2 infection: a multicenter European study.
- A serological assay to detect SARS-CoV-2 antibodies in at-home collected finger-prick dried blood spots.
November 2020
- Development and validation of a highly sensitive and specific electrochemical assay to quantify anti-SARS-CoV-2 IgG antibodies to facilitate pandemic surveillance and monitoring of vaccine response.
- Multiplexed, quantitative serological profiling of COVID-19 from a drop of blood by a point-of-care test.
- *Research Tool Development of an automated chemiluminescence assay system for quantitative measurement of multiple anti-SARS-CoV-2 antibodies.
- *Research Tool Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies.
- *Research Tool Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies.
- First performance report of QIAreach™ Anti-SARS-CoV-2 Total Test, an innovative nanoparticle fluorescence digital detection platform.
- *Research Tool A Novel In-Cell ELISA Assay Allows Rapid and Automated Quantification of SARS-CoV-2 to Analyze Neutralizing Antibodies and Antiviral Compounds.
- Evaluation of the Abbott Architect, Roche Elecsys and Virtus S1 SARS-CoV-2 antibody tests in community-managed COVID-19 cases.
- Comparative performance of five commercially available serologic assays to detect antibodies to SARS-CoV-2 and identify individuals with high neutralizing titers.
- *Research Tool A multiplex microsphere IgG assay for SARS-CoV-2 using ACE2-mediated inhibition as a surrogate for neutralization.
- Highly Sensitive and Specific Multiplex Antibody Assays To Quantify Immunoglobulins M, A, and G against SARS-CoV-2 Antigens.
- *Research Tool Accurate Diagnosis of COVID-19 by a Novel Immunogenic Secreted SARS-CoV-2 orf8 Protein.
- Point-of-Need Disposable ELISA System for COVID-19 Serology Testing.
October 2020
- A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19.
- *Research Tool From multiplex serology to serolomics: A novel approach to the antibody response against the SARS-CoV-2 proteome.
- Multiplexed detection and quantification of human antibody response to COVID-19 infection using a plasmon enhanced biosensor platform.
- Capillary whole-blood IgG-IgM COVID-19 self-test as a serological screening tool for SARS-CoV-2 infection adapted to the general public.
- Accuracy of point-of-care diagnostic tests for SARS-CoV-2 antibodies (IgM/IgG) is heterogeneous.
- A high-throughput microfluidic nano-immunoassay for detecting anti-SARS-CoV-2 antibodies in serum or ultra-low volume dried blood samples.
- Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers and convalescent plasma donors.
- Application, Verification and Implementation of SARS-CoV-2 Serologic Assays with Emergency Use Authorization.
- COVID-19 seroprevalence surveys and antibody decline - A note of caution on antibody decline.
- Sensitive Detection of SARS-CoV-2-Specific Antibodies in Dried Blood Spot Samples.
- Rapid Determination of SARS-CoV-2 Antibodies Using a Bedside, Point-of-Care, Serological Test.
September 2020
- Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding.
- Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19.
- Serological Assays Estimate Highly Variable SARS-CoV-2 Neutralizing Antibody Activity in Recovered COVID-19 Patients.
- Comparative performance of five commercially available serologic assays to detect antibodies to SARS-CoV-2 and identify individuals with high neutralizing titers.
- Detection of antibodies against SARS-CoV-2 spike protein by gold nanospikes in an opto-microfluidic chip.
- Evaluation of Abbott Anti-SARS-CoV-2 CMIA IgG and Euroimmun ELISA IgG/IgA Assays In a Clinical Lab.
- A simple protein-based surrogate neutralization assay for SARS-CoV-2.
- Multiplexed Detection and Quantification of Human Antibody Response to COVID-19 Infection Using a Plasmon Enhanced Biosensor Platform.
- Two serological approaches for detection of antibodies to SARS-CoV-2 in different scenarios: a screening tool and a point-of-care test.
- Development and validation of a multiplex bead based assay for the detection of antibodies directed against SARS-CoV-2 proteins.
- SARS-CoV-2 assays to detect functional antibody responses that block ACE2 recognition in vaccinated animals and infected patients.
- Diagnostic significance of SARS-CoV-2 IgM positive/IgG negative antibody profile in symptomatic patients with suspected COVID-19 testing negative by RT-PCR.
- Detection of SARS-CoV-2 IgG by Four Nucleocapsid or Spike Protein-Targeting High-Throughput Immunoassays Authorized for Emergency Use.
- A highly specific and sensitive serological assay detects SARS-CoV-2 antibody levels in COVID-19 patients that correlate with neutralization.
- Multi-species ELISA for the detection of antibodies against SARS-CoV-2 in animals.
August 2020
- High seroprevalence for SARS-CoV-2 among household members of essential workers detected using a dried blood spot assay.
- Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection.
- ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection.
- Evaluation of a novel multiplexed assay for determining IgG levels and functional activity to SARS-CoV-2.
- SARS-CoV-2-specific ELISA development.
- Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results.
- Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity.
- Rapid quantitative screening assay for SARS-CoV-2 neutralizing antibodies using HiBiT-tagged virus-like particles.
- Serial Profiling of SARS-CoV-2 Antigens and Antibodies in COVID-19 Patient Plasma.
- A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction.
July 2020
- Rapid and sensitive detection of SARS-CoV-2 antibodies by biolayer interferometry.
- Dynamics and significance of the antibody response to SARS-CoV-2 infection.
- D614G Spike Variant Does Not Alter IgG, IgM, or IgA Spike Seroassay Performance.
- Analytical and clinical validation of an ELISA for specific SARS-CoV-2 IgG, IgA and IgM antibodies.
- Evaluation of six commercial mid to high volume antibody and six point of care lateral flow assays for detection of SARS-CoV-2 antibodies.
- An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment.
- Laboratory Assay Evaluation Demystified: A Review of Key Factors Influencing Interpretation of Test Results Using Different Assays for SARS-CoV-2 Infection Diagnosis.
- Novel SARS-CoV-2 specific antibody and neutralization assays reveal wide range of humoral immune response during COVID-19.
- Multiplex detection and dynamics of IgG antibodies to SARS-CoV2 and the highly pathogenic human coronaviruses SARS-CoV and MERS-CoV.
- Association between neutralizing antibodies to SARS-CoV-2 and commercial serological assays.
- COVID-19 serology at population scale: SARS-CoV-2-specific 2 antibody responses in saliva.
- The COVID-19 Serology Studies Workshop: Recommendations and Challenges.
- Hospital-Wide SARS-CoV-2 Antibody Screening in 3056 Staff in a Tertiary Center in Belgium.
- Development and validation of IMMUNO-COV™: a high-throughput clinical assay for detecting antibodies that neutralize SARS-CoV-2.
- A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring.
- Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses.
June 2020
- Performance of six SARS-CoV-2 immunoassays in comparison with microneutralisation.
- SARS-CoV-2-specific antibody detection for sero-epidemiology: a multiplex analysis approach accounting for accurate seroprevalence.
- When To Retest: an Examination of Repeat COVID-19 PCR Patterns in an Ambulatory Population.
- Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma.
- Detection of antibodies to the SARS-CoV-2 spike glycoprotein in both serum and saliva enhances detection of infection.
- Serological differentiation between COVID-19 and SARS infections.
- Optimizing high-yield production of SARS-CoV-2 soluble spike trimers for serology assays.
- Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China.
- Alltest rapid lateral flow immunoassays is reliable in diagnosing SARS-CoV-2 infection from 14 days after symptom onset: A prospective single-center study.
- A Modular Microarray Imaging System for Highly Specific COVID-19 Antibody Testing.
- Diagnostic performance of 7 rapid IgG/IgM antibody tests and the Euroimmun IgA/IgG ELISA in COVID-19 patients.
May 2020
- Serology characteristics of SARS-CoV-2 infection since exposure and post symptom onset.
- SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area.
- Standardization of enzyme-linked immunosorbent assays for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling.
- Longitudinal Monitoring of SARS-CoV-2 IgM and IgG Seropositivity to Detect COVID-19.
- A serological assay to detect SARS-CoV-2 seroconversion in humans.
- Evaluation of two automated and three rapid lateral flow immunoassays for the detection of anti-SARS-CoV-2 antibodies.
- Clinical Performance of Two SARS-CoV-2 Serologic Assays.
- Evaluation of commercial and automated SARS-CoV-2 IgG and IgA ELISAs using coronavirus disease (COVID-19) patient samples.
- Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.
- Serology assays to manage COVID-19.
- ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens.
- Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model.
April 2020
- Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020.
- SARS-CoV-2 serological analysis of COVID-19 hospitalized patients, pauci-symptomatic individuals and blood donors.
- Test performance evaluation of SARS-CoV-2 serological assays.
- Detection of Nucleocapsid Antibody to SARS-CoV-2 is More Sensitive than Antibody to Spike Protein in COVID-19 Patients.
- Diagnostic accuracy of an automated chemiluminescent immunoassay for anti-SARS-CoV-2 IgM and IgG antibodies: an Italian experience.
- Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor.
- Antibody Detection and Dynamic Characteristics in Patients with COVID-19.
- Evaluation of antibody testing for SARS-Cov-2 using ELISA and lateral flow immunoassays.
- The convalescent sera option for containing COVID-19.
- Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease 2019 Patients.
- Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019.
- Evaluation of Nucleocapsid and Spike Protein-based ELISAs for detecting antibodies against SARS-CoV-2.
- Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2.