Registry COVID-19 Research Registry
Top COVID-19 Research: Timely, Curated and Vetted by Experts
Vaccine Boosters for Children 5 to 11 Authorized
This week, global COVID-19 cases increased for the first time in weeks. U.S. cases have steadily increased for the past month among all age groups, including children. The U.S. Food and Drug Administration (FDA) authorized a booster dose of the Pfizer & BioNTech mRNA vaccine for children 5 through 11 years old this week. Primary and booster vaccine doses induce effective protection to variants of concern, which is important as over 99% of new cases in the U.S. are caused by Omicron. Published this week in Nature Microbiology, Yung, M., et al. detected memory T cells that respond to the Omicron spike protein in samples from individuals vaccinated with 2 or 3 doses of the Pfizer & BioNTech mRNA vaccine. Increased vaccine access and equity along with masking and social distancing are all ways to help slow the spread of SARS-CoV-2.
Therapeutics Effective Against Variants
Therapeutics provide additional protection against severe disease caused by new variants. Tested in a hamster model, Rosenke, K., et al. in JCI Insight found the oral antiviral molnupiravir inhibited virus replication of the Alpha, Beta, Delta and Omicron variants. Uraki, R., et al. also observed effective viral inhibition of Omicron BA.2 by molnupiravir, with additional SARS-CoV-2 main protease inhibitors and some monoclonal antibody therapies also retaining activity to Omicron BA.2 in their Nature article. Researchers are also developing broad antivirals and next-generation vaccines specifically targeting variants for current and emerging variants.
Preparing for Emerging Variants
SARS-CoV-2 will continue to evolve, making it critical to prepare and plan for new variants. Thank you to all who participated in the registry’s virtual discussion on emerging variants this week. I especially want to thank Drs. Esther Babady, Florian Krammer and Penny Moore for sharing their insights and highlighting the need for continued surveillance, neutralization assays and constant monitoring of diagnostics and therapeutics’ efficacy as first steps when variants arise. Collaborative networks that allow for rapid and easy sharing of data among academic, commercial, public health and government sources supported by sustained and global funding will help scientists become proactive instead of reactive to new variants. These collaborations can be used to respond to other global pathogens, such as HIV, and emerging outbreaks, such as monkeypox cases recently reported in Europe and the U.S. For our part, the registry will continue to provide timely and high-impact resources for the community. While there have been many good and thorough papers about COVID-19 published, the registry curated only those that are novel, high quality, relevant and fill a vital knowledge gap in our selected categories to provide a one-stop-shop of authoritative information of fundamental research on SARS-CoV-2.Lynn Enquist, Ph.D.
Our Registry is supported in part through generous donations from supporters like you. Please consider donating to ASM to help us continue our work.
Explore ASM's COVID-19 Initiatives View Sequencing and Surveillance Resources Learn about the Omicron Variant
How is the genome of SARS-CoV-2 evolving? What mechanism does the coronavirus use to target human cells? How does the immune system react to SARS-CoV-2?
Will serology provide the ultimate answer? Does the existence of the antibody equal protection due to antibody neutralization? How often should patients be tested?
What are the results of the newest treatment? What drugs are in the pipeline? What are the latest outcomes from clinical trials?
What are the different kinds of vaccines? Do coronaviruses evolve to escape vaccines? What have we learned from work with Ebola virus and SARS vaccines development?
How does a pandemic start? How long will this pandemic last: can data models give us some hints? COVID-19 affects people differently depending on their age, how does this affect transmission? How does social distancing influence transmission rates?
Scientifically speaking, what is a coronavirus? What are the similarities and differences in structure and activities of SARS, MERS and SARS-CoV-2? What is the PK/PD of Remdesivir?
Biweekly Commentary Letter
By Jonathan D. Dinman, Ph.D., Professor of Cell Biology and Molecular Genetics, University of Maryland, College Park, Md. Dinman is a curator of the registry.
"Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism" by Strobelt et al., published in Scientific Reports on April 6, 2022.
View the Commentary on ASM Connect View Past Commentaries
- Audio Interview: "Understanding the Omicron Variant of SARS-CoV-2" Feb. 24, 2022.
- Audio Interview: "Covid-19 Vaccination and the Omicron Variant" Dec. 30, 2021.
- "How booster shots can help protect you from Omicron" Dec. 17, 2021.
- Audio Interview: "The Omicron Variant of SARS-CoV-2" Dec. 2, 2021.
- Coronapod: "Everything we know about the new COVID variant" Nov. 26, 2021.
- "Are COVID-19 Vaccine Boosters Needed? The Science behind Boosters" Nov. 24, 2021.
- Dr. Vaughn Cooper: "Evolutionary biology of SARS-CoV-2" March 23, 2021 (YouTube 1:01:46).
- COVID-19 Conversations: "Variants and Vaccines" March 17, 2021 (1:27:06).
- Scientific panel discussion on the new variant, 501Y.V2 Jan. 18, 2021 (1:58:28).
- Dr. Vaughn Cooper: "The ongoing evolution of SARS-CoV-2" April 1, 2020 (YouTube11:21).
- Dr. Pamela Bjorkman: "Intro to Viruses, Antivirals, and Vaccines" April 10, 2020 (YouTube 52:57).
- Dr. Scott Page: "Understanding Fatality Rate Models" April 3, 2020 (YouTube 10:12).
- Minute Physics: "How to tell if we’re beating Covid-19" March 27, 2020 (YouTube 7:15).
- 3 Blue 1 Brown "Simulating an Epidemic" March 27, 2020 (YouTube 2:07).
- Dr. Britt Glaunsinger: "Coronaviruses 101, Focus on Molecular Virology" March 25, 2020 (YouTube 1:02:18).
- Dr. Vaughn Cooper: "Evolutionary Biology of Novel Coronavirus SARS-CoV-2" March 24, 2020 (YouTube 11:48).
- Pennings and colleagues: "How does SARS-CoV-2 spread?" March 24, 2020 (Vimeo 8:25).
- Dr. Nick Jewell: "The Exponential Power of Now" March 19, 2020 (YouTube 1:06:00).
- Online Marty: "Disease Spread Simulation" March 18, 2020 (YouTube 2:52).
- Pennings and colleagues: "Coronavirus in numbers" March 11, 2020 (Vimeo 10:18).
- Pennings: "SARS-CoV-2 and phylogenetic trees" March 2, 2020 (Vimeo 14:15).
- University of Pennsylvania: "Coronavirus Outbreak Symposium" April 3, 2020 (YouTube).
- Audio Interview: "Vaccine Efficacy and Boosters in Covid-19" Sept. 23, 2021.
- This Week In Virology: "COVID-19 clinical update #79 with Dr. Daniel Griffin" Sept. 11, 2021.
- Audio Interview: "Another New Covid-19 Vaccine" July 1, 2021.
- Coronapod: "CureVac disappoints in COVID vaccine trial" June 18, 2021 (13:29).
- Coronapod: "The variant blamed for India's catastrophic second wave" May 14, 2021 (8:36).
- Audio Interview: "The Real-World Effectiveness of Covid-19 Vaccination" Feb. 25, 2021.
- Audio Interview: "Covid-19 in South Africa and a New SARS-CoV-2 Variant" Jan. 14, 2021.
- Antimicrobial Agents and Chemotherapy (AAC) Podcast: "Therapeutic approaches for COVID-19: Myths and Facts" May 5, 2020.
- DIY Transcriptomics.
- "COVID-360: A Collaborative Effort to Develop a Multidisciplinary Set of Online Resources for Engaging Teaching on the COVID-19 Pandemic" March 2021 (J. Microbiol. Biol. Educ.).
- "Analysis of a COVID-19 Clinical Trial to Emphasize Experimental Design and Quantitative Reasoning in an Introductory Biology Course" March 2021 (J. Microbiol. Biol. Educ.).
- "Genome Analysis of SARS-CoV-2 Case Study: An Undergraduate Online Learning Activity To Introduce Bioinformatics, BLAST, and the Power of Genome Databases" March 2021 (J. Microbiol. Biol. Educ.).
- "COVID-19, SARS-CoV-2 and the Pandemic" (MIT Free Course).
- Coursera: "Fighting COVID-19 with Epidemiology: A Johns Hopkins Teach-Out" (Free Course).
- "COVID vaccine immunity is waning — how much does that matter?" Sept. 17, 2021.
- "Evolution of the COVID-19 vaccine development landscape" Sept. 4, 2021.
- "Not just antibodies: B cells and T cells mediate immunity to COVID-19" Aug. 24, 2021.
- "How the coronavirus infects cells — and why Delta is so dangerous" July 28, 2021.
- "A correlate of protection for SARS-CoV-2 vaccines is urgently needed" July 8, 2021.
- "How Immunity Generated from COVID-19 Vaccines Differs from an Infection" June 22, 2021.
- "Antibody (Serology) Tests for COVID-19: a Case Study" May 12, 2021.
- "What scientists know about new, fast-spreading coronavirus variants" May 24, 2021.
- "Pfizer COVID vaccine protects against worrying coronavirus variants" May 6, 2021.
- "One million coronavirus sequences: popular genome site hits mega milestone" April 23, 2021.
- "Pandemic Response Catalyst Conversations: Validating & Sharing Scientific Information" Oct. 13, 2020.
- Atul Gawande: "Amid the Coronavirus Crisis, a Regimen for Re-entry" May 13, 2020.
- Dougan and Holt: “How to make a new COVID-19 vaccine starting from scratch” April 9, 2020.