Registry COVID-19 Research Registry
Top COVID-19 Research: Timely, Curated and Vetted by Experts
COVID-19 Vaccine Boosters Authorized for Older Adults
This week, the U.S. Food and Drug Administration authorized booster doses of the Pfizer & BioNTech Comirnaty vaccine for select groups. The CDC endorsed boosters at least 6 months after vaccination for individuals 65 and older, long-term care residents, individuals with underlying medical conditions and those with high "occupational exposure." These additional doses are intended to "boost" protection against COVID-19. However, there is debate if vaccine boosters are needed for the general population. COVID-19 vaccines continue to provide effective and durable protection against hospitalization for at least 20 weeks across all age groups as reported in a preprint by de Gier, B., et al. Stay updated on the latest science about boosters at the COVID-19 Research Registry’s new section about Vaccine Boosters.
Vaccines Induce Durable Protective Immunity
Recent data indicate vaccines induce enduring immunity. El Sahly, H., et al. showed in The New England Journal of Medicine the Moderna mRNA-1273 vaccine remained highly protective against COVID-19 for at least 5 months post full vaccination. In Science, Mateus, J., et al. demonstrated the mRNA-1273 vaccine elicited immune memory SARS-CoV-2-specific T cells and antibodies for at least 6 months. For the Janssen Ad26.COV2.S vaccine, Polinski, J., et al. determined the efficacy against infection (79%) and hospitalizations (81%) remained stable over time while the Delta variant became dominate. Dr. Catherine J. Pachuk, Chief Science Officer, Marizyme, Inc., addressed the longevity of protection from this vaccine in this week’s commentary on the article "Durability of antibody responses elicited by a single dose of Ad26.COV2.S and substantial increase following late boosting." Sadoff, J., et al. observed stable neutralizing antibody titers for 8 to 9 months post vaccination with the Ad26.COV2.S vaccine, though titers decreased over 2-fold in those 65 and older. The authors also followed a group who received an additional dose 6 months after vaccination, finding a rapid 9-fold increase in antibody levels after the booster. Pachuk notes this rapid response indicates primary vaccination induced "robust immune memory," suggesting vaccinated individuals may be protected against severe COVID-19.
Are Boosters Needed to Overcome Coronavirus Adaptive Evolution?
Published in Nature, Schmidt, F., et al. reported that highly resistant SARS-CoV-2 strains can be neutralized by sera from individuals infected then vaccinated. These data highlight the resilience of the immune response and indicate a high-level of viral evolution is needed for complete immune escape. Thank you to presenter Dr. Jesse Bloom and panelists Drs. Sarah Cobey, Katia Koelle and Dylan Morris for discussing this topic at our COVID-19 Research Registry Virtual Journal Club. And thank you to everyone who joined our robust discussion on the impact of adaption evolution for immune escape and a possible need for boosters. All the panelists stressed that current vaccines are highly effective and vaccinating the global population should be a priority. Vaccine inequity currently exists where only 2.2% of people from low-income countries have received at least one dose, with Cobey stating that "boosters coming at the expense of first vaccinations" may not be the most effective strategy to control the pandemic globally.Lynn Enquist, Ph.D.
How is the genome of SARS-CoV-2 evolving? What mechanism does the coronavirus use to target human cells? How does the immune system react to SARS-CoV-2?
Will serology provide the ultimate answer? Does the existence of the antibody equal protection due to antibody neutralization? How often should patients be tested?
What are the results of the newest treatment? What drugs are in the pipeline? What are the latest outcomes from clinical trials?
What are the different kinds of vaccines? Do coronaviruses evolve to escape vaccines? What have we learned from work with Ebola virus and SARS vaccines development?
How does a pandemic start? How long will this pandemic last: can data models give us some hints? COVID-19 affects people differently depending on their age, how does this affect transmission? How does social distancing influence transmission rates?
Scientifically speaking, what is a coronavirus? What are the similarities and differences in structure and activities of SARS, MERS and SARS-CoV-2? What is the PK/PD of Remdesivir?
Biweekly Commentary Letter
By Catherine J. Pachuk, Ph.D., Chief Science Officer, Marizyme, Inc., Jupiter, Fla. Pachuk is one of the curators of the Registry.
- This Week In Virology: "COVID-19 clinical update #79 with Dr. Daniel Griffin" Sept. 11, 2021.
- "Evolution of the COVID-19 vaccine development landscape" Sept. 4, 2021.
- "Not just antibodies: B cells and T cells mediate immunity to COVID-19" Aug. 24, 2021.
- "How the coronavirus infects cells — and why Delta is so dangerous" July 28, 2021.
- "A correlate of protection for SARS-CoV-2 vaccines is urgently needed" July 8, 2021.
- Dr. Vaughn Cooper: "Evolutionary biology of SARS-CoV-2" March 23, 2021 (YouTube 1:01:46).
- COVID-19 Conversations: "Variants and Vaccines" March 17, 2021 (1:27:06).
- Scientific panel discussion on the new variant, 501Y.V2 Jan. 18, 2021 (1:58:28).
- Dr. Vaughn Cooper: "The ongoing evolution of SARS-CoV-2" April 1, 2020 (YouTube11:21).
- Dr. Pamela Bjorkman: "Intro to Viruses, Antivirals, and Vaccines" April 10, 2020 (YouTube 52:57).
- Dr. Scott Page: "Understanding Fatality Rate Models" April 3, 2020 (YouTube 10:12).
- Minute Physics: "How to tell if we’re beating Covid-19" March 27, 2020 (YouTube 7:15).
- 3 Blue 1 Brown "Simulating an Epidemic" March 27, 2020 (YouTube 2:07).
- Dr. Britt Glaunsinger: "Coronaviruses 101, Focus on Molecular Virology" March 25, 2020 (YouTube 1:02:18).
- Dr. Vaughn Cooper: "Evolutionary Biology of Novel Coronavirus SARS-CoV-2" March 24, 2020 (YouTube 11:48).
- Pennings and colleagues: "How does SARS-CoV-2 spread?" March 24, 2020 (Vimeo 8:25).
- Dr. Nick Jewell: "The Exponential Power of Now" March 19, 2020 (YouTube 1:06:00).
- Online Marty: "Disease Spread Simulation" March 18, 2020 (YouTube 2:52).
- Pennings and colleagues: "Coronavirus in numbers" March 11, 2020 (Vimeo 10:18).
- Pennings: "SARS-CoV-2 and phylogenetic trees" March 2, 2020 (Vimeo 14:15).
- University of Pennsylvania: "Coronavirus Outbreak Symposium" April 3, 2020 (YouTube).
- Audio Interview: "Another New Covid-19 Vaccine" July 1, 2021.
- Coronapod: "CureVac disappoints in COVID vaccine trial" June 18, 2021 (13:29).
- Coronapod: "The variant blamed for India's catastrophic second wave" May 14, 2021 (8:36).
- Audio Interview: "The Real-World Effectiveness of Covid-19 Vaccination" Feb. 25, 2021.
- Audio Interview: "Covid-19 in South Africa and a New SARS-CoV-2 Variant" Jan. 14, 2021.
- Antimicrobial Agents and Chemotherapy (AAC) Podcast: "Therapeutic approaches for COVID-19: Myths and Facts" May 5, 2020.
- DIY Transcriptomics.
- "COVID-360: A Collaborative Effort to Develop a Multidisciplinary Set of Online Resources for Engaging Teaching on the COVID-19 Pandemic" March 2021 (J. Microbiol. Biol. Educ.).
- "Analysis of a COVID-19 Clinical Trial to Emphasize Experimental Design and Quantitative Reasoning in an Introductory Biology Course" March 2021 (J. Microbiol. Biol. Educ.).
- "Genome Analysis of SARS-CoV-2 Case Study: An Undergraduate Online Learning Activity To Introduce Bioinformatics, BLAST, and the Power of Genome Databases" March 2021 (J. Microbiol. Biol. Educ.).
- "COVID-19, SARS-CoV-2 and the Pandemic" (MIT Free Course).
- Coursera: "Fighting COVID-19 with Epidemiology: A Johns Hopkins Teach-Out" (Free Course).
- "How Immunity Generated from COVID-19 Vaccines Differs from an Infection" June 22, 2021.
- "Antibody (Serology) Tests for COVID-19: a Case Study" May 12, 2021.
- "What scientists know about new, fast-spreading coronavirus variants" May 24, 2021.
- "Pfizer COVID vaccine protects against worrying coronavirus variants" May 6, 2021.
- "One million coronavirus sequences: popular genome site hits mega milestone" April 23, 2021.
- "Pandemic Response Catalyst Conversations: Validating & Sharing Scientific Information" Oct. 13, 2020.
- Atul Gawande: "Amid the Coronavirus Crisis, a Regimen for Re-entry" May 13, 2020.
- Dougan and Holt: “How to make a new COVID-19 vaccine starting from scratch” April 9, 2020.
Who We Are
Coronavirus experts and ASM staff working together to bring forward the top COVID-19 research studies to the community.
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