Top COVID-19 Research: Timely, Curated and Vetted by Experts
ASM is keeping the pulse of the SARS-CoV-2 pandemic. In the eye of a pandemic, the need for a trusted, up-to-date resource of coronavirus research plays a crucial role in supporting the scientific community on the frontlines fighting the virus.
This registry includes top-ranked, COVID-19 research articles curated by experts and serves as a resource for scientists working together to address fundamental science and accelerate scientific research on SARS-CoV-2.
How is the genome of SARS-CoV-2 evolving? What mechanism does the coronavirus use to target human cells? How does the immune system react to SARS-CoV-2?
Will serology provide the ultimate answer? Does the existence of the antibody equal protection due to antibody neutralization? How often should patients be tested?
What are the results of the newest treatment? What drugs are in the pipeline? What are the latest outcomes from clinical trials?
What are the different kinds of vaccines? Do coronaviruses evolve to escape vaccines? What have we learned from work with Ebola virus and SARS vaccines development?
How does a pandemic start? How long will this pandemic last: can data models give us some hints? COVID-19 affects people differently depending on their age, how does this affect transmission? How does social distancing influence transmission rates?
Scientifically speaking, what is a coronavirus? What are the similarities and differences in structure and activities of SARS, MERS and SARS-CoV-2? What is the PK/PD of Remdesivir?
COVID-19 Research Registry - Editorial Volume 2
The number of published and pre-print articles continues to accelerate over the past 3 months, which has presented some significant challenges. We screened over 2,500 articles each week to select relevant and high-quality papers to populate the registry. This effort is a partnership between ASM staff and my colleagues in the curatorial board and curators team. I cannot thank them enough for their hard work and contributions!
Besides the sheer volume of papers, another challenge is to balance different viewpoints and to present objective and credible science to the scientific community. It is not easy when new findings come out every week and conflicting results appear. Our goal is to collect the best papers and resolve conflicts by keeping ourselves updated with the rapid development of the field. Your suggestions and opinions are welcomed and greatly appreciated.
Starting in Aug., we will add a new activity to the registry. The curatorial board will host a monthly COVID-19 Registry Virtual Journal Club on the third Thursday of each month at 2 p.m. EST. The inaugural event will take place on Thursday, Aug. 20 at 2 p.m. EST. We envision this will be a robust forum to engage the research community and interested learners in scientific discussions, collaborative networking and information sharing on the topic of research and discoveries on SARS-CoV-2 and other coronaviruses. Please mark your calendar. Registration information will be available at the beginning of Aug.
Biweekly Commentary Letter
Jan. 22, 2021By Jonathan D. Dinman, Ph.D., Professor of Cell Biology and Molecular Genetics, University of Maryland, College Park, Md., U.S. Dr. Dinman is one of the curators of the registry.
“SARS-CoV-2 protein ORF3a is pathogenic in Drosophila and causes phenotypes associated with COVID-19 post-viral syndrome” by Yang, S., et al., published in bioRxiv on Dec. 20, 2020.
A majority of COVID-19 patients suffer from post-recovery neurological complications including extreme fatigue and neuropsychiatric symptoms. Although a growing number of animal models, including non-human primates and hACE2 transgenic mice, have been developed to elucidate molecular mechanisms underlying the acute disease, the relatively long generation times of these mammalian systems render dissection of the bases for the long-term sequelae impractical, especially in light of the urgency attending the growing number of potential patients.
This study leveraged the power of Drosophila molecular genetics and developmental biology to address this pressing issue. Additionally, the rapid lifecycle of this model organism enables the types of longitudinal studies that would take months if not years in humans and non-human primate models. In this proof of principle work, Drosophila strains were constructed expressing the SARS-CoV-2 ORF3a protein in tissue specific manner. The authors found significant phenotypes only in flies’ expression of ORF3a in the nervous system. These included reduced lifespan, impaired motor function, abdominal swelling and partial larval lethality. Follow-up studies revealed that ORF3a expression induced apoptosis, neuroinflammation and neurotropism though immunoinflammatory pathways. The ability of ORF3a to cause lysosome deacidification suggested that this may be a source of toxic stress in neural cells. As proof of principle, transgenic flies treated with chloroquine phosphate, which blocks lysosome deacidification, increased ORF3a expressing fly lifespan, improved motor function and larval survival suggesting that chloroquine treatment may ameliorate symptoms associated with SARS-CoV-2 associated post-viral syndrome in humans. This study also validates the fly system as a platform for targeting specific proteins and pathways for drug screening.
Video & Other Curricular Resources for COVID-19
- “COVID-19, SARS-CoV-2 and the Pandemic”.
- Antimicrobial Agents and Chemotherapy (AAC) Podcast: Therapeutic approaches for COVID-19: Myths and Facts.
- Science Forum: SARS-CoV-2 (COVID-19) by the numbers.
- Vaughn Cooper: “The ongoing evolution of SARS-CoV-2” April 1, 2020 (YouTube11:21).
- Dr. Pamela Bjorkman: Intro to Viruses, Antivirals, and Vaccines April 10, 2020 (YouTube 52:57).
- Scott Page: Understanding Fatality Rate Models April 3, 2020 (YouTube 10:12).
- Minute Physics: "How to tell if we’re beating Covid-19" March 27, 2020 (YouTube 7:15).
- 3 Blue 1 Brown "Simulating an Epidemic" March 27, 2020 (YouTube 2:07).
- Britt Glaunsinger: "Coronaviruses 101, Focus on Molecular Virology" March 25, 2020 (YouTube 1:02:18).
- Vaughn Cooper: "Evolutionary Biology of Novel Coronavirus SARS-CoV-2" March 24, 2020 (YouTube 11:48).
- Pennings and colleagues: "How does SARS-CoV-2 spread?" March 24, 2020 (Vimeo 8:25).
- Nick Jewell "The Exponential Power of Now" March 19, 2020 (YouTube 1:06:00).
- Online Marty: "Disease Spread Simulation" March 18, 2020 (YouTube 2:52).
- Pennings and colleagues: "Coronavirus in numbers" March 11, 2020 (Vimeo 10:18).
- Pennings: "SARS-CoV-2 and phylogenetic trees" March 2, 2020 (Vimeo 14:15).
- University of Pennsylvania: "Coronavirus Outbreak Symposium" April 3, 2020 (YouTube).
- Coursera: Fighting COVID-19 with Epidemiology: A Johns Hopkins Teach-Out (Free Course).
Blogs, Articles and Opinions
- COVID-19 Disease Map: a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms.
- Pandemic Response: Validating and Sharing Scientific Information.
- Atul Gawande: Amid the Coronavirus Crisis, a Regimen for Re-entry.
- Dougan and Holt: “How to make a new COVID-19 vaccine starting from scratch” April 9, 2020.
Who We Are
Coronavirus experts and ASM staff working together to bring forward the top COVID-19 research studies to the community.
Email suggestions for research to be highlighted in the COVID-19 Registry.