Top COVID-19 Research: Timely, Curated and Vetted by Experts
From the Curator-in-Chief's Desk—July 23, 2021
Global COVID-19 cases and deaths continue to rise this week, fueled by the Delta (B.1.617.2) variant. Over 80% of new COVID-19 cases are caused by the Delta variant in the U.S., where cases have tripled in the last 2 weeks. Fortunately, current vaccines reduce SARS-CoV-2 transmission. Prunas, O., et al. determined the Pfizer and BioNTech BNT162b2 vaccine is 88.5% effective at preventing SARS-CoV-2 transmission among households. COVID-19 vaccines are a safe and effective way to help reduce the spread of SARS-CoV-2.
COVID-19 vaccines are also highly effective against SARS-CoV-2 variants. Lopez Bernal, J., et al. assessed vaccine effectiveness of 2 doses of the BNT162b2 and the AstraZeneca ChAdOx1-S nCoV-19 vaccines against symptomatic disease. The authors reported the vaccine efficacy of BNT162b2 is 93.7% against the Alpha (B.1.1.7) variant and 88% against the Delta variant. The ChAdOx1-S nCoV-19 vaccine is 74.5% and 67% effective against the Alpha and Delta variants, respectively. Vaccines also reduce the severity of disease for individuals infected with the Delta variant. Kumar, V., et al. analyzed disease severity in vaccinated and unvaccinated patients hospitalized with COVID-19 infected with the Delta variant. Compared to unvaccinated patients, fully vaccinated patients had 50% lower rates of needing a ventilator and mortality.
The need for vaccine boosters is a current debate. France and Israel recommend additional doses for vulnerable populations that had reduced immune responses. Tada, T., et al. measured neutralizing activity of sera from individuals vaccinated with the BNT162b2, Moderna mRNA-1273 and Janssen Ad26.COV2.S vaccines against a panel of variants including Alpha, Beta (B.1.351) and Delta. The authors found high cross-neutralization of antibodies induced by 2 doses of the mRNA vaccines but decreased neutralization from antibodies elicited by a single dose of the Ad26.COV2.S vaccine, with the authors suggesting a second dose of the Ad26.COV2.S to increase immune protection from variants. This week, the CDC Advisory Committee on Immunization Practices met to discuss the need for boosters for COVID-19 vaccines, especially for immunocompromised individuals. The advisory committee stated more data was needed before making a formal recommendation.
The situation of the Delta variant has evolved rapidly, and the scientific community is working hard to answer some pressing questions about the vaccines and guidance for the public. Although the recent findings need to be further confirmed, they are hopeful. While waiting for more research to give us further answers, it is clear that COVID-19 vaccines do help, and we desperately need more people to be vaccinated to control the spread. Extra precautions may be needed to give us time to reach herd immunity safely.
How is the genome of SARS-CoV-2 evolving? What mechanism does the coronavirus use to target human cells? How does the immune system react to SARS-CoV-2?
Will serology provide the ultimate answer? Does the existence of the antibody equal protection due to antibody neutralization? How often should patients be tested?
What are the results of the newest treatment? What drugs are in the pipeline? What are the latest outcomes from clinical trials?
What are the different kinds of vaccines? Do coronaviruses evolve to escape vaccines? What have we learned from work with Ebola virus and SARS vaccines development?
How does a pandemic start? How long will this pandemic last: can data models give us some hints? COVID-19 affects people differently depending on their age, how does this affect transmission? How does social distancing influence transmission rates?
Scientifically speaking, what is a coronavirus? What are the similarities and differences in structure and activities of SARS, MERS and SARS-CoV-2? What is the PK/PD of Remdesivir?
Biweekly Commentary Letter
By Frederick G. Hayden, M.D., Stuart S Richardson Professor Emeritus of Clinical Virology and Professor Emeritus of Medicine in the Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Va. Hayden is one of the curators of the registry.
"Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial" by the RECOVERY Collaborative Group, published on medRxiv on June 16, 2021.
View the Commentary on ASM Connect View Past Commentaries
- Audio Interview: Another New Covid-19 Vaccine July 1, 2021.
- DIY Transcriptomics.
- How Immunity Generated from COVID-19 Vaccines Differs from an Infection June 22, 2021.
- Coronapod: CureVac disappoints in COVID vaccine trial June 18, 2021 (13:29).
- What scientists know about new, fast-spreading coronavirus variants May 24, 2021.
- Coronapod: The variant blamed for India's catastrophic second wave May 14, 2021 (8:36).
- Antibody (Serology) Tests for COVID-19: a Case Study May 12, 2021.
- Dr. Vaughn Cooper: "Evolutionary biology of SARS-CoV-2" March 23, 2021 (YouTube 1:01:46).
- COVID-19 Conversations: Variants and Vaccines March 17, 2021 (1:27:06).
- Scientific panel discussion on the new variant, 501Y.V2 Jan. 18, 2021 (1:58:28).
- Dr. Vaughn Cooper: "The ongoing evolution of SARS-CoV-2" April 1, 2020 (YouTube11:21).
- Dr. Pamela Bjorkman: "Intro to Viruses, Antivirals, and Vaccines" April 10, 2020 (YouTube 52:57).
- Dr. Scott Page: "Understanding Fatality Rate Models" April 3, 2020 (YouTube 10:12).
- Minute Physics: "How to tell if we’re beating Covid-19" March 27, 2020 (YouTube 7:15).
- 3 Blue 1 Brown "Simulating an Epidemic" March 27, 2020 (YouTube 2:07).
- Dr. Britt Glaunsinger: "Coronaviruses 101, Focus on Molecular Virology" March 25, 2020 (YouTube 1:02:18).
- Dr. Vaughn Cooper: "Evolutionary Biology of Novel Coronavirus SARS-CoV-2" March 24, 2020 (YouTube 11:48).
- Pennings and colleagues: "How does SARS-CoV-2 spread?" March 24, 2020 (Vimeo 8:25).
- Dr. Nick Jewell: "The Exponential Power of Now" March 19, 2020 (YouTube 1:06:00).
- Online Marty: "Disease Spread Simulation" March 18, 2020 (YouTube 2:52).
- Pennings and colleagues: "Coronavirus in numbers" March 11, 2020 (Vimeo 10:18).
- Pennings: "SARS-CoV-2 and phylogenetic trees" March 2, 2020 (Vimeo 14:15).
- University of Pennsylvania: "Coronavirus Outbreak Symposium" April 3, 2020 (YouTube).
- Audio Interview: The Real-World Effectiveness of Covid-19 Vaccination Feb. 25, 2021.
- Audio Interview: Covid-19 in South Africa and a New SARS-CoV-2 Variant Jan. 14, 2021.
- Antimicrobial Agents and Chemotherapy (AAC) Podcast: Therapeutic approaches for COVID-19: Myths and Facts May 5, 2020.
- COVID-360: A Collaborative Effort to Develop a Multidisciplinary Set of Online Resources for Engaging Teaching on the COVID-19 Pandemic March 2021 (J. Microbiol. Biol. Educ.).
- Analysis of a COVID-19 Clinical Trial to Emphasize Experimental Design and Quantitative Reasoning in an Introductory Biology Course March 2021 (J. Microbiol. Biol. Educ.).
- Genome Analysis of SARS-CoV-2 Case Study: An Undergraduate Online Learning Activity To Introduce Bioinformatics, BLAST, and the Power of Genome Databases March 2021 (J. Microbiol. Biol. Educ.).
- “COVID-19, SARS-CoV-2 and the Pandemic” (MIT Free Course).
- Coursera: "Fighting COVID-19 with Epidemiology: A Johns Hopkins Teach-Out" (Free Course).
- Pfizer COVID vaccine protects against worrying coronavirus variants May 6, 2021.
- One million coronavirus sequences: popular genome site hits mega milestone April 23, 2021.
- Pandemic Response Catalyst Conversations: Validating & Sharing Scientific Information Oct. 13, 2020.
- Atul Gawande: "Amid the Coronavirus Crisis, a Regimen for Re-entry" May 13, 2020.
- Dougan and Holt: “How to make a new COVID-19 vaccine starting from scratch” April 9, 2020.
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Coronavirus experts and ASM staff working together to bring forward the top COVID-19 research studies to the community.
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