Registry COVID-19 Research Registry
Top COVID-19 Research: Timely, Curated and Vetted by Experts
COVID-19 Vaccine for Kids Under 5 Authorized
Children under the age of 5 in the U.S. may soon be able to join the more than 65% of the world’s population that is vaccinated against SARS-CoV-2. This week, the U.S. Food and Drug Administration (FDA) granted emergency use authorization for the Pfizer & BioNTech and Moderna COVID vaccines for children 6 months to 5 years old. Both Pfizer & BioNTech’s 3-dose and Moderna’s 2-dose regimes were found to be safe and effective against severe COVID-19. As reported cases in the U.S. plateau, a vaccine for vulnerable populations like children is especially necessary. Yuan, Y., et al. also observed a ~50% higher rate in hospitalizations for disability-eligible Medicare beneficiaries compared to age-eligible beneficiaries in this week’s Morbidity and Mortality Weekly Report. The authors noted the importance of increasing vaccine distribution and treatment access to high-risk groups, which is needed both in the U.S. and globally.
BA.4 and BA.5 can Escape Omicron-Induced Immunity
Highly transmissible variants foster viral spread. Numerous new variants have been identified because of increased genomic sequencing. Most recently, the Omicron sublineages BA.4 and BA.5 emerged. Dr. Vito Martella, University Aldo Moro of Bari, described the new sublineages in this week’s curator commentary on ASM Connect. In their preprint "Continued Emergence and Evolution of Omicron in South Africa: New BA.4 and BA.5 lineages," Tegally, H., et al. identified and monitored the BA.4 and BA.5 sublineages in South Africa in early 2022. By April 2022, the authors found more than 50% of all sequenced cases belonged to these sublineages, estimating slight growth advantages for BA.4 and BA.5 over Omicron BA.2. In regards to BA.4 and BA.5’s impact on immunity, Cao, Y., et al. found BA.4 and BA.5 escaped neutralization from antibodies induced by vaccination or previous infection with the Omicron BA.1 lineage in their Nature article published this week.
Global Sequencing to Inform Pandemic Response
Martella highlighted that consistent and global sequencing along with research to characterize variants’ virology and immune escape abilities will be "pivotal to re-shape our response to COVID-19 pandemic" moving forward. In May, the Registry hosted a special virtual panel on the scientific community’s response to emerging variants. Drs. Esther Babady, Florian Krammer and Penny Moore all spoke about building international collaborations that connect genomic sequencing and basic science to diagnostics and therapeutics used in clinics and in the field. Understanding the genomic landscape as well as the immunological landscape—such as the impact of past treatment, infection and vaccination on future immunity—will be critical to mitigating the pandemic. If you were unable to attend, you can find a recording on our archive page, where you can also watch all our past COVID-19 Research Registry Virtual Clubs sessions.Lynn Enquist, Ph.D.
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Explore ASM's COVID-19 Initiatives Watch the Registry's Special Virtual Panel on Emerging Variants Read Past Commentaries
How is the genome of SARS-CoV-2 evolving? What mechanism does the coronavirus use to target human cells? How does the immune system react to SARS-CoV-2?
Will serology provide the ultimate answer? Does the existence of the antibody equal protection due to antibody neutralization? How often should patients be tested?
What are the results of the newest treatment? What drugs are in the pipeline? What are the latest outcomes from clinical trials?
What are the different kinds of vaccines? Do coronaviruses evolve to escape vaccines? What have we learned from work with Ebola virus and SARS vaccines development?
How does a pandemic start? How long will this pandemic last: can data models give us some hints? COVID-19 affects people differently depending on their age, how does this affect transmission? How does social distancing influence transmission rates?
Scientifically speaking, what is a coronavirus? What are the similarities and differences in structure and activities of SARS, MERS and SARS-CoV-2? What is the PK/PD of Remdesivir?
Biweekly Commentary Letter
By Yi-Wei Tang, M.D., Ph.D., F(AAM), FIDSA, chief medical officer, Danaher Diagnostic Platform and Cepheid (China), Shanghai. Tang is a curator of the registry.
"A Single-Round Infection Fluorescent SARS-CoV-2 Neutralization Test for COVID-19 Serological Testing at a Biosafety Level-2 Laboratory" by Zou, J. et al., published in Viruses on June 2, 2022.
View the Commentary on ASM Connect View Past Commentaries
- Audio Interview: "Understanding the Omicron Variant of SARS-CoV-2" Feb. 24, 2022.
- Audio Interview: "Covid-19 Vaccination and the Omicron Variant" Dec. 30, 2021.
- "How booster shots can help protect you from Omicron" Dec. 17, 2021.
- Audio Interview: "The Omicron Variant of SARS-CoV-2" Dec. 2, 2021.
- Coronapod: "Everything we know about the new COVID variant" Nov. 26, 2021.
- "Are COVID-19 Vaccine Boosters Needed? The Science behind Boosters" Nov. 24, 2021.
- Dr. Vaughn Cooper: "Evolutionary biology of SARS-CoV-2" March 23, 2021 (YouTube 1:01:46).
- COVID-19 Conversations: "Variants and Vaccines" March 17, 2021 (1:27:06).
- Scientific panel discussion on the new variant, 501Y.V2 Jan. 18, 2021 (1:58:28).
- Dr. Vaughn Cooper: "The ongoing evolution of SARS-CoV-2" April 1, 2020 (YouTube11:21).
- Dr. Pamela Bjorkman: "Intro to Viruses, Antivirals, and Vaccines" April 10, 2020 (YouTube 52:57).
- Dr. Scott Page: "Understanding Fatality Rate Models" April 3, 2020 (YouTube 10:12).
- Minute Physics: "How to tell if we’re beating Covid-19" March 27, 2020 (YouTube 7:15).
- 3 Blue 1 Brown "Simulating an Epidemic" March 27, 2020 (YouTube 2:07).
- Dr. Britt Glaunsinger: "Coronaviruses 101, Focus on Molecular Virology" March 25, 2020 (YouTube 1:02:18).
- Dr. Vaughn Cooper: "Evolutionary Biology of Novel Coronavirus SARS-CoV-2" March 24, 2020 (YouTube 11:48).
- Pennings and colleagues: "How does SARS-CoV-2 spread?" March 24, 2020 (Vimeo 8:25).
- Dr. Nick Jewell: "The Exponential Power of Now" March 19, 2020 (YouTube 1:06:00).
- Online Marty: "Disease Spread Simulation" March 18, 2020 (YouTube 2:52).
- Pennings and colleagues: "Coronavirus in numbers" March 11, 2020 (Vimeo 10:18).
- Pennings: "SARS-CoV-2 and phylogenetic trees" March 2, 2020 (Vimeo 14:15).
- University of Pennsylvania: "Coronavirus Outbreak Symposium" April 3, 2020 (YouTube).
- Audio Interview: "Vaccine Efficacy and Boosters in Covid-19" Sept. 23, 2021.
- This Week In Virology: "COVID-19 clinical update #79 with Dr. Daniel Griffin" Sept. 11, 2021.
- Audio Interview: "Another New Covid-19 Vaccine" July 1, 2021.
- Coronapod: "CureVac disappoints in COVID vaccine trial" June 18, 2021 (13:29).
- Coronapod: "The variant blamed for India's catastrophic second wave" May 14, 2021 (8:36).
- Audio Interview: "The Real-World Effectiveness of Covid-19 Vaccination" Feb. 25, 2021.
- Audio Interview: "Covid-19 in South Africa and a New SARS-CoV-2 Variant" Jan. 14, 2021.
- Antimicrobial Agents and Chemotherapy (AAC) Podcast: "Therapeutic approaches for COVID-19: Myths and Facts" May 5, 2020.
- DIY Transcriptomics.
- "COVID-360: A Collaborative Effort to Develop a Multidisciplinary Set of Online Resources for Engaging Teaching on the COVID-19 Pandemic" March 2021 (J. Microbiol. Biol. Educ.).
- "Analysis of a COVID-19 Clinical Trial to Emphasize Experimental Design and Quantitative Reasoning in an Introductory Biology Course" March 2021 (J. Microbiol. Biol. Educ.).
- "Genome Analysis of SARS-CoV-2 Case Study: An Undergraduate Online Learning Activity To Introduce Bioinformatics, BLAST, and the Power of Genome Databases" March 2021 (J. Microbiol. Biol. Educ.).
- "COVID-19, SARS-CoV-2 and the Pandemic" (MIT Free Course).
- Coursera: "Fighting COVID-19 with Epidemiology: A Johns Hopkins Teach-Out" (Free Course).
- "COVID vaccine immunity is waning — how much does that matter?" Sept. 17, 2021.
- "Evolution of the COVID-19 vaccine development landscape" Sept. 4, 2021.
- "Not just antibodies: B cells and T cells mediate immunity to COVID-19" Aug. 24, 2021.
- "How the coronavirus infects cells — and why Delta is so dangerous" July 28, 2021.
- "A correlate of protection for SARS-CoV-2 vaccines is urgently needed" July 8, 2021.
- "How Immunity Generated from COVID-19 Vaccines Differs from an Infection" June 22, 2021.
- "Antibody (Serology) Tests for COVID-19: a Case Study" May 12, 2021.
- "What scientists know about new, fast-spreading coronavirus variants" May 24, 2021.
- "Pfizer COVID vaccine protects against worrying coronavirus variants" May 6, 2021.
- "One million coronavirus sequences: popular genome site hits mega milestone" April 23, 2021.
- "Pandemic Response Catalyst Conversations: Validating & Sharing Scientific Information" Oct. 13, 2020.
- Atul Gawande: "Amid the Coronavirus Crisis, a Regimen for Re-entry" May 13, 2020.
- Dougan and Holt: “How to make a new COVID-19 vaccine starting from scratch” April 9, 2020.