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This white paper was initially posted in Oct. 2016 and has been updated as of Nov. 2022 

The emergence of plasmid-mediated mobile colistin resistance (mcr) genes in Enterobacterales occurred in 2015. Soon after, the Centers for Disease Control and Prevention (CDC) released an alert to increase awareness and emphasize the importance of monitoring the prevalence of mcr genes in clinical isolates of Enterobacterales. Because the mcr-1 gene continues to be the most predominant mcr type and the most frequently associated with clinical infections in humans, this guideline focuses on the laboratory testing and epidemiology of the mcr-1 gene

This guideline was developed on behalf of the American Society for Microbiology Clinical and Public Health Microbiology Committee, Laboratory Practices Subcommittee. 

Contact Information  

ASM's Clinical and Public Health Microbiology Committee,