This exercise is a role-playing activity to demonstrate the cellular basis of standard antibiotics. Students are assigned roles either as organelles or antibiotics. Those players representing organelles demonstrate the standard processes of transcription, translation, replication, and endocytosis. Students who have been assigned antibiotic roles join the action in progress without revealing their identity. The audience and players can be assessed on the basis of their ability to identify the antibiotic by its action, or the audience can try to score points as part of an elaborate charades game.