From discovering new antibiotics, to implementing policies that steward existing drugs in the antimicrobial toolbox, this issue of Microcosm explores antimicrobial resistance (AMR) and how to combat one of the largest threats to global public health and the environment.
How has antimicrobial resistance research informed the evolution of both U.S. and international policy over the past 10 years? In the multifaceted fight against AMR, microbiologists and policymakers play key roles.
Certain practices, such as uncontrolled spraying of fungicides, in plant agriculture and crop production are known to facilitate the spread of pathogenic, resistant microbes to human consumers. Understanding how antimicrobial resistance spreads from farm to fork is key to growing healthy crops, and not superbugs.
The rise of antifungal resistant pathogens like Candida auris and Aspergillus fumigatus is sounding alarms. How common is antifungal resistance? Who is at risk? What pathogens are of particular concern, and how significant is the overall threat?
Local experts in Ethiopia, Mozambique and Tanzania share strategies for combating AMR, emphasizing the need for equitable health care interventions, as well as sustained laboratory and workforce development.
Antimicrobial resistance advances through the interaction between humans, animals and the environment. Understanding how wastewater spreads AMR is critical to defeating this global menace.
AMR was ranked the third-leading cause of death for Pakistanis in 2019, behind only cardiovascular disease and maternal/neonatal disorders. Insights from strategies being applied to combat this threat in Pakistan can serve as a case study to help inform a One Health approach to combat AMR worldwide.
Implementing outpatient and inpatient antimicrobial stewardship programs, especially in Federally Qualified Health Centers, requires multidisciplinary teams and sustained educational efforts.
Evidence about optimal treatment approaches for infections caused by antimicrobial resistant organisms changes over time. So too should clinical breakpoints for antimicrobial susceptibility testing.
As the antimicrobial resistance crisis grows, so does the need to discover new antibiotics. To find them, scientists are sifting through extracts from unusual and (once) unculturable microbes.
From molecular de-extinction in drug discovery to investigating clove oil as an adjuvant to combat colistin resistance and applications for phage therapy to treat acne, learn about what’s hot in the microbial sciences.
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Explore the latest groundbreaking research in the microbial sciences, stay up-to-date with what's happening at ASM and read cutting-edge scientific articles in Microcosm, ASM's flagship, members-only magazine.
Virginia L. Miller, Ph.D.
University of North Carolina at Chapel Hill
Theresa M. Koehler, Ph.D.
McGovern Medical School, University of Texas
Robin Patel, M.D.
Victor DiRita, Ph.D.
Michigan State University
Stefano Bertuzzi, Ph.D.