Enhancing a virus with magnetic nanoparticles and CRISPR-Cas gene editing abilities makes it a good vector for genetic therapies!
Microbe of the episode
Viruses can help with both delivery and modification, but they're often not specific and targeted enough to be effective, or even safe. Off-target effects could be harmful or even deadly, potentially resulting in cancer.
In this study, a virus is modified with nanotechnology in the form of tiny magnets to allow humans to target it to specific tissues, and given the ability to modify specific genes using the bacterial CRISPR-Cas system. These modifications potentially make this gene delivery system much more safe and effective.
Other interesting stories
- Bacteria found in hot, dry areas could have potentially useful industrial enzymes (paper)
- Gut bacteria help regulate vitamin A activity in gut
- Confined swimming bacteria form shifting vortex like clothes washer (paper)