Using phages to target gold nanoparticles to infect bacteria, then using light to heat the nanoparticles just enough to kill the bacteria!
Thanks to Huan Peng and Raymond Borg for contributing!
News item: A controlled phage therapy can target drug-resistant bacteria while sidestepping potential unintended consequences
Microbe of the episode
Microbe of the episode: Pantoea agglomerans
This study circumvents these questions by using phages for delivery and targeting of bacteria rather than the therapeutic agent itself. The actual treatment is done with tiny rods of gold, gold nanorods, bound to the phage surface. When a certain wavelength of light hits these nanorods, they vibrate enough to generate enough heat in their immediate surroundings to render nearby bacteria nonviable. Thus the infection is treated in a very localized, targeted way that doesn't leave any active bacteria or phages behind. The authors have plans to study this approach as a topical treatment of wounds.
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