Food Contaminant Deoxynivalenol Exacerbates Damage to DNA in Gut Microbiota

March 14, 2017

Washington, D.C. – Tuesday, March 14, 2017 – Researchers from the University of Toulouse, France have demonstrated through in vitro and in vivo results that the intestinal DNA damage induced by colibactin-producing Escherichia coli strains was exacerbated by the presence of the mycotoxin Deoxynivalenol (DON) in the diet. This finding raises questions about the synergism between food contaminants and gut microbiota with regard to intestinal carcinogenesis. The research is published this week in mBio, an open-access journal of the American Society for Microbiology.

An increasing number of human beings from developed countries are colonized by E. coli strains producing colibactin, a genotoxin suspected to be associated with the development of colorectal cancers. Deoxynivalenol (DON) is the most prevalent mycotoxin that contaminates staple food—especially cereal products—in Europe and North America. image: iStock photo

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