Join research experts in discussing recent journal articles posted to ASM's COVID-19 Research Registry. The Virtual Journal Club sessions are held on the third Thursday of the month at 2 p.m. Eastern Time. Registration for each month's session opens on the first of the month.

March 18 Session

Registration opens March 1.

The selected study examines the potential of antiviral molecules to inhibit the replication of SARS-CoV-2 and reduce the overall inflammatory response to infection. Our presenter and panelists, with their diverse expertise, will lead an in-depth discussion of the findings and explore the role of broad-spectrum antiviral agents to suppress the inflammatory response as a means to control disease severity. 

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Authors: David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan and Christian K. Holm.

Nature Communications  02 Oct 2020 
DOI: 10.1038/s41467-020-18764-3

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

Moderator

Rozanne M. Sandri-Goldin, Ph.D.

Rozanne M. Sandri-Goldin, Ph.D.

University of California Irvine

Presenter

Mark Heise, Ph.D.
The University of North Carolina at Chapel Hill

Discussion Panel

Matthew Frieman, Ph.D.
University of Maryland School of Medicine

Sabra Klein, Ph.D.
Johns Hopkins Bloomberg School of Public Health

Timothy Sheahan, Ph.D. 
University of North Carolina at Chapel Hill's Gillings School of Global Public Health

Next Session 

April 15, 2021, 2 p.m. ET (registration will open April 1)

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Recordings are available free to ASM members.

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Contact Information

COVID-19 Registry Team, covid19registry@asmusa.org