Simple genome sequences, like those of bacteriophage (bacterial viruses), are excellent resources for teaching students about genome analysis. This exercise allows students to annotate the genome of the bacteriophage 933W, a virus isolated from pathogenic Escherichia coli O157:H7. Students use Internet-based resources in class to add annotations for products and functions to genes from 933W based on queries against genome and protein databases. By the end of class, students will have annotated a simple genome and learned about the various methods and steps involved in adding annotations to genes in a genome database.