Watch past COVID-19 Research Registry virtual journal club session where SARS-CoV-2 research is presented and discussed in depth by a panel of experts.
- Oct. 20, 2022—"The Future of Long COVID."
- May 19, 2022—Special Virtual Panel on Emerging Variants: "After Omicron—How to Respond to the Next Variant?"
- April 14, 2022—"Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses."
- March 17, 2022—"Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles."
- Feb. 17, 2022 - "The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages."
- Nov. 18, 2021—"mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status."
- Oct. 28, 2021—"Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells" and "mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern."
- Sept. 23, 2021—"A human coronavirus evolves antigenically to escape antibody immunity" and "Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e."
- Aug. 19, 2021—"A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells."
- July 15, 2021—"Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L."
- April 15, 2021—"The variant gambit: COVID-19’s next move."
- March 18, 2021—"SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate."
- Feb. 18, 2021—"IgA dominates the early neutralizing antibody response to SARS-CoV-2."
- Nov. 19, 2020—"Evasion of Type I Interferon by SARS-CoV-2."
- Oct. 15, 2020—"A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants."
- Sept. 17, 2020—"Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice."
- Aug. 20, 2020—"Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate."
Oct. 20, 2022
Much remains unknown about long COVID, including the causes or risk-factors. Experts share current and future efforts to understand the mechanisms and treatments for long COVID.
May 19, 2022
SARS-CoV-2 variants are constantly emerging. So how should the scientific community respond when a new variant of concern arises? Experts discuss what experiments regarding vaccines, diagnostics and therapeutics are needed right away.
April 14, 2022
Article under discussion: "Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses."
Authors: Tianyang Mao, Benjamin Israelow, Alexandra Suberi, Liqun Zhou, Melanie Reschke, Mario A Peña-Hernández, Huiping Dong, Robert J. Homer, W. Mark Saltzman and Akiko Iwasaki.
March 17, 2022
Authors: Abdullah M. Syed, Taha Y. Taha, Takako Tabata, Irene P. Chen, Alison Ciling, Mir M. Khalid, Bharath Sreekumar, Pei-Yi Chen, Jennifer M. Hayashi, Katarzyna M. Soczek, Melanie Ott and Jennifer A. Doudna.
Feb. 17, 2022
Authors: Darren P. Martin, Steven Weaver, Houriiyah Tegally, James Emmanuel San, Stephen D. Shank, Eduan Wilkinson, Alexander G. Lucaci, Jennifer Giandhari, Sureshnee Naidoo, Yeshnee Pillay, Lavanya Singh, Richard J. Lessells, NGS-SA, COVID-19 Genomics UK (COG-UK), Ravindra K. Gupta, Joel O. Wertheim, Anton Nekturenko, Ben Murrell, Gordon W. Harkins, Philippe Lemey, Oscar A. MacLean, David L. Robertson, Tulio de Oliveira and Sergei L. Kosakovsky Pond.
Nov. 18, 2021
Article under discussion: "mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status."
Authors: Jason Neidleman, Xiaoyu Luo, Matthew McGregor, Guorui Xie, Victoria Murray, Warner C. Greene, Sulggi A. Lee and Nadia R. Roan.
Oct. 28, 2021
Articles under discussion: "Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells" and "mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern"
Article 1 authors: Kristen W. Cohen, Susanne L. Linderman, Zoe Moodie, Julie Czartoski, Lilin Lai, Grace Mantus, Carson Norwood, Lindsay E. Nyhoff, Venkata Viswanadh Edara, Katharine Floyd, Stephen C. De Rosa, Hasan Ahmed, Rachael Whaley, Shivan N. Patel, Brittany Prigmore, Maria P. Lemos, Carl W. Davis, Sarah Furth, James B. O’Keefe, Mohini P. Gharpure, Sivaram Gunisetty, Kathy Stephens, Rustom Antia, Veronika I. Zarnitsyna, David S. Stephens, Srilatha Edupuganti, Nadine Rouphael, Evan J. Anderson, Aneesh K. Mehta, Jens Wrammert, Mehul S. Suthar, Rafi Ahmed and M. Juliana McElrath.
Article 2 authors: Rishi R. Goel, Mark M. Painter, Sokratis A. Apostolidis, Divij Mathew, Wenzhao Meng, Aaron M. Rosenfeld, Kendall A. Lundgreen, Arnold Reynaldi, David S. Khoury, Ajinkya Pattekar, Sigrid Gouma, Leticia Kuri-Cervantes, Philip Hicks, Sarah Dysinger, Amanda Hicks, Harsh Sharma, Sarah Herring, Scott Korte, Amy E. Baxter, Derek A. Oldridge, Josephine R. Giles, Madison E. Weirick, Christopher M. McAllister, Moses Awofolaju, Nicole Tanenbaum, Elizabeth M. Drapeau, Jeanette Dougherty, Sherea Long, Kurt D’Andrea, Jacob T. Hamilton, Maura McLaughlin, Justine C. Williams, Sharon Adamski, Oliva Kuthuru, Ian Frank, Michael R. Betts, Laura A. Vella, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Scott E. Hensley, Miles P. Davenport, Paul Bates, Eline T. Luning Prak, Allison R. Greenplate and E. John Wherry.
Sept. 23, 2021
Articles under discussion: "A human coronavirus evolves antigenically to escape antibody immunity" and "Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e."
Article 1 authors: Rachel T. Eguia, Katharine H. D. Crawford, Terry Stevens-Ayers, Laurel Kelnhofer-Millevolte, Alexander L. Greninger, Janet A. Englund, Michael J. Boeckh and Jesse D. Bloom.
Article 2 authors: Kathryn E Kistler and Trevor Bedford.
Aug. 19, 2021
Article under discussion: "A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells."
Authors: Matthew Mahoney, Vishnu C. Damalanka, Michael A. Tartell, Dong Hee Chung, André Luiz Lourenco, Dustin Pwee, Anne E. Mayer Bridwell, Markus Hoffmann, Jorine Voss, Partha Karmakar, Nurit Azouz, Andrea M. Klingler, Paul W. Rothlauf, Cassandra E. Thompson, Melody Lee, Lidija Klampfer, Christina Stallings, Marc E. Rothenberg, Stefan Pöhlmann, Sean P. Whelan, Anthony J. O’Donoghue, Charles S. Craik and James W. Janetka.
July 15, 2021
Article under discussion: "Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L."
Authors: Michael Dominic Sacco, Chunlong Ma, Panagiotis Lagarias, Ang Gao, Julia Alma Townsend, Xiangzhi Meng, Peter Dube, Xiujun Zhang, Yanmei Hu, Naoya Kitamura, Brett Hurst, Bart Tarbet, Michael Thomas Marty, Antonios Kolocouris, Yan Xiang, Yu Chen and Jun Wang.
April 15, 2021
Article under discussion: "The variant gambit: COVID-19’s next move."
Authors: Jessica A. Plante, Brooke M. Mitchell, Kenneth S. Plante, Kari Debbink, Scott C. Weaver, and Vineet D. Menachery.
March 18, 2021
Article under discussion: "SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate."
Authors: David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan and Christian K. Holm.
Feb. 18, 2021
Article under discussion: "IgA dominates the early neutralizing antibody response to SARS-CoV-2."
Authors: Delphine Sterlin, Alexis Mathian, Makoto Miyara, Audrey Mohr, François Anna, Laetitia Claër, Paul Quentric, Jehane Fadlallah, Hervé Devilliers, Pascale Ghillani, Cary Gunn, Rick Hockett, Sasi Mudumba, Amélie Guihot, Charles-Edouard Luyt, Julien Mayaux, Alexandra Beurton, Salma Fourati, Timothée Bruel, Olivier Schwartz, Jean-Marc Lacorte, Hans Yssel, Christophe Parizot, Karim Dorgham, Pierre Charneau, Zahir Amoura, and Guy Gorochov.
Nov. 19, 2020
Article under discussion: "Evasion of Type I Interferon by SARS-CoV-2."
Authors: Hongjie Xia, Zengguo Cao, Xuping Xie, Xianwen Zhang, John Yun-Chung Chen, Hualei Wang, Vineet D. Menachery, Ricardo Rajsbaum, and Pei-Yong Shi.
Oct. 15, 2020
Article under discussion: "A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants."
Authors: Bethany Dearlove, Eric Lewitus, Hongjun Bai, Yifan Li, Daniel B. Reeves, M. Gordon Joyce, Paul T. Scott, Mihret F. Amare, Sandhya Vasan, Nelson L. Michael, Kayvon Modjarrad, Morgane Rolland.
Sept. 17, 2020
Article under discussion: "Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice."
Authors: Andrea J. Pruijssers, Amelia S. George, Alexandra Schäfer, Sarah R. Leist, Lisa E. Gralinksi, Kenneth H. Dinnon III, Boyd L. Yount, Maria L. Agostini, Laura J. Stevens, James D. Chappell, Xiaotao Lu, Tia M. Hughes, Kendra Gully, David R. Martinez, Ariane J. Brown, Rachel L. Graham, Jason K. Perry, Venice Du Pont, Jared Pitts, Bin Ma, Darius Babusis, Eisuke Murakami, Joy Y. Feng, John P. Bilello, Danielle P. Porter, Tomas Cihlar, Ralph S. Baric, Mark R. Denison, and Timothy P. Sheahan.
Aug. 20, 2020
Article under discussion: "Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate."
Authors: Christiane Iserman, Christine Roden, Mark Boerneke, Rachel Sealfon, Grace McLaughlin, Irwin Jungreis, Chris Park, Avinash Boppana, Ethan Fritch, Yixuan J. Hou, Chandra Theesfeld, Olga G Troyanskaya, Ralph S. Baric, Timothy P. Sheahan, Kevin Weeks, Amy S. Gladfelter.